Association of left atrial volume and function by CMR with clinical and imaging findings in hypertrophic cardiomyopathy
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Objective: To evaluate the correlation of left atrial (LA) volume and function assessed by cardiac magnetic resonance (CMR) with selected clinical and imaging findings in patients with hypertrophic cardiomyopathy (HCM).
Subjects and Methods: A cross-sectional descriptive study was conducted on 58 patients diagnosed with HCM at Bach Mai Hospital from March 2024 to October 2025. All patients underwent CMR imaging to assess LA volume (LAVmax, LAVmin, LAVpreA) and LA function (LAEFp, LAEFa, LAEFt, LA strain) using the specialized software CVI42 (Circle Cardiovascular Imaging). Correlations were analyzed using IBM SPSS Statistics for Windows, version 20.0.
Results: The mean age was 56.6 ± 18.0 years, with a male-to-female ratio of 1.4:1. Significant correlations were found of LA indices with:
(1) Dyspnea severity: LA volume progressively increased and function decreased with worsening dyspnea.
(2) Extent of Late Gadolinium Enhancement (LGE): Moderate to strong correlations were observed with all LA volume and function indices (all p < 0.01).
(3) Left Ventricular Mass (LVM): Moderate correlation with LAEFp (r = -0.39, p = 0.003) but no correlation with LAEFa and LAEFt. Maximal left ventricular wall thickness (Max LVWT) showed no significant correlation (p > 0.05).
Conclusion: CMR-derived LA volume and function indices demonstrate a strong correlation with dyspnea severity and the extent of LGE (myocardial fibrosis) but show a weak correlation with the degree of left ventricular hypertrophy.
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2. Freed BH, Shah SJ. Stepping out of the Left Ventricle’s Shadow: Time to Focus on the Left Atrium in Heart Failure with Preserved Ejection Fraction. Circ Cardiovasc Imaging. 2017.
3. Farhad H, Seidelmann SB, Vigneault D, et al. Left Atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy. J Cardiovasc Magn Reson. 2017;19(1):107.
4. Yang H, Woo A, Monakier D, et al. Enlarged left atrial volume in hypertrophic cardiomyopathy: a marker for disease severity. J Am Soc Echocardiogr. 2005;18(10):1074-1082.
5. Thao Mai Thanh, Linh Nguyen Dai Hung, Thuy Tran Thi Mai, Chien Phan Cong. Characteristics of late gadolinium enhancement on cardiac magnetic resonance in hypertrophic cardiomyopathy. VJRNM. 2020;(39):11-22.
6. Thoa Vu Thi Kim, Luu Vu Dang, Viet Nguyen Khoi, et al. Magnetic resonance imaging characteristics of hypertrophic cardiomyopathy. VJRNM. 2022.
7. Ommen SR, Mital S, Burke MA, et al. 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy. Circulation. 2020;142(25): 558-631.
8. Tian D, Zhang J, He Y, et al. Predictive value of left atrial strain analysis in adverse clinical events in patients with hypertrophic cardiomyopathy: a CMR study. BMC Cardiovasc Disord. 2023;23(1):42.