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Date Published: 11/07/2022
Online Published: 11/07/2022
Abstract Views: 89
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DOI: https://doi.org/10.55046/vjrnm.25.630.2016
Issue
No. 25 (2016)
Section
Scientific research
How to Cite
Pham, C. H., Nguyen, D. H., & Nguyen, D. H. (2022). Value of proton MR spectroscopy in grading of oligodendroglial tumors. Vietnamese Journal of Radiology and Nuclear Medicine, 25, 4-9. https://doi.org/10.55046/vjrnm.25.630.2016

Value of proton MR spectroscopy in grading of oligodendroglial tumors

Dr Pham Chu Hoang1, Dr Nguyen Duy Hung1, Dr Nguyen Duy Hue1
1 Imaging dept, Vietnam-Germany Hospital; School Ha Noi medical university

Main Article Content

Abstract

Objective of this study is to describe the value of Proton MR Spectroscopy in predicting preoperative oligodendroglioma
grading. Between 05/2015and 04/2016, a cross-sectional study involved 31 patients (15 high-grade oligodendroglioma
and 16 low-grade oligodendroglioma) underwent preoperative conventional MR Imaging, Proton MR Spectroscopy and
histopathologically determined oligodendrogliomas after stereotactic biopsy or resection. Receiver operating characteristic
(ROC) curve was used to determine the accuracy of Cho/NAA, Cho/Cr and NAA/Cr ratios, the area under the curve of whom
is largest is chosen to obtain cut-off value. Cho/NAA ratio was measured as 2.32 ± 1.06 and 5.85 ± 5.42 in low-grade and highgrade oligodendrogliomas, respectively. The Cho/NAA ratio from high-grade oligodendrogliomas was statistically different
from those of low-grade oligodendrogliomas (p<0.001). The cut-off value was taken as 3.057 in the Cho/NAA ratio provided
sensitivity, specificity, PPV and NPV of 73.33%; 75%; 73.33% and 75%, respectively. Inconclusion, Spectroscopy MRI is useful
in the preoperative assessment of the histopathological grade of oligodendrogliomas.

Article Details

Keywords

Oligodendroglioma grading, Proton MRSpectroscopy Imaging.

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