THE VALUE OF HIGH-RESOLUTION T2-WEIGHTED MRI TO EVALUATE LOCAL STAGING OF RECTAL CANCER

Pham Thi Men1,, Tran Duc Huy1, Le Van Khang2, Vu Dang Luu2
1 Hanoi Medical University
2 Radiology Center, Bach Mai Hospital, Hanoi, Vietnam

Main Article Content

Abstract

Purpose: To describe imaging characteristics of rectal cancer on high-resolution T2-weighted MRI in predicting local staging of rectal cancer


Materials and methods: A cross-sectional descriptive study aimed at evaluating the sensitivity, specificity, accuracy, and correlation coefficient of MRI in staging T (tumor) and N (lymph node involvement) in patients with rectal cancer. The study used a high-resolution T2 weighted on 3 Tesla MRI to assess the pre-treatment stage compared with histopathology results after surgery.


Results: The study involved a sample of 48 patients, consisting of 27 men and 21 women. The pre-treatment stage was assessed using magnetic resonance imaging (MRI), considering stages as T1, T2, T3, and T4 were 2 (4.2%), 6 (12.5%), 36 (75%) and 4 (8.3%); staged as N0, N1, N2 were 19 (39.6%), 17 (35.4%), 4 (8.3%). A total of 21 patients underwent surgical procedures, and this study aimed to evaluate the sensitivity, specificity, and accuracy of MRI with a high-resolution T2 weighted in comparison to the overall postoperative pathology were 100%, 75%, 90.5% for T1-3 staging and 75%, 76.92%, 76.19% for N0-2 staging. The κ values were 0.714 and 0.199 for T1-3 and N0-2 staging, respectively.


Conclusion: MRI with a high-resolution T2 weighted has significant value in the diagnosis of local staging of rectal cancer, particularly in determining the T stage. The precise local staging plays a crucial role in selecting the appropriate treatment methods, and prolongation of survival time for individuals with rectal cancer.

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References

1. Hong, Y.; Kim, J.; Choi, Y. J.; Kang, J. G. Clinical Study of Colorectal Cancer Operation: Survival Analysis. Korean J Clin Oncol 2020, 16 (1), 3–8. https://doi.org/10.14216/kjco.20002.
2. Akasu, T.; Iinuma, G.; Takawa, M.; Yamamoto, S.; Muramatsu, Y.; Moriyama, N. Accuracy of High-Resolution Magnetic Resonance Imaging in Preoperative Staging of Rectal Cancer. Ann Surg Oncol 2009, 16 (10), 2787– 2794. https://doi.org/10.1245/s10434-009-0613-3.
3. Brown: Rectal carcinoma: thin-section MR imaging... - Google Scholar. https://scholar.google.com/scholar_ lookup?title=Rectal%20carcinoma%3A%20thin-section%20MR%20imaging%20for%20staging%20in%2028%20 patients&publication_year=1999&author=G.%20Brown&author=C.J.%20Richards&author=R.G.%20Newcombe (accessed 2023-07-29).
4. Rovera, F.; Dionigi, G.; Boni, L.; Cutaia, S.; Diurni, M.; Dionigi, R. The Role of EUS and MRI in Rectal Cancer Staging. Surg Oncol 2007, 16 Suppl 1, S51-52. https://doi.org/10.1016/j.suronc.2007.10.038.
5. Suzuki, C.; Torkzad, M. R.; Tanaka, S.; Palmer, G.; Lindholm, J.; Holm, T.; Blomqvist, L. The Importance of Rectal Cancer MRI Protocols on iInterpretation Accuracy. World J Surg Oncol 2008, 6, 89. https://doi.org/10.1186/14777819-6-89.
6. Torkzad, M. R.; Hansson, K. A.; Lindholm, J.; Martling, A.; Blomqvist, L. Significance of Mesorectal Volume in Staging of Rectal Cancer with Magnetic Resonance Imaging and the Assessment of Involvement of the Mesorectal Fascia. Eur Radiol 2007, 17 (7), 1694–1699. https://doi.org/10.1007/s00330-006-0521-x.
7. Videhult, P.; Smedh, K.; Lundin, P.; Kraaz, W. Magnetic Resonance Imaging for Preoperative Staging of Rectal Cancer in Clinical Practice: High Accuracy in Predicting Circumferential Margin with Clinical Benefit. Colorectal Dis 2007, 9 (5), 412–419. https://doi.org/10.1111/j.1463-1318.2006.01167.x.
8. Sethi: Contemporary coloproctology - Google Scholar. ttps://scholar.google.com/scholar_lookup?title=Contemp orary+coloproctology&author=R+Sethi&author=SH.+Lee&publication_year=2012& (accessed 2023-07-29).
9. Poon, F. W.; McDonald, A.; Anderson, J. H.; Duthie, F.; Rodger, C.; McCurrach, G.; McKee, R. F.; Horgan, P. G.; Foulis, A. K.; Chong, D.; Finlay, I. G. Accuracy of Thin Section Magnetic Resonance Using Phased-Array Pelvic Coil in Predicting the T-Staging of Rectal Cancer. Eur J Radiol 2005, 53 (2), 256–262. https://doi.org/0.1016/j. ejrad.2004.03.011.
10. Rao, S.-X.; Zeng, M.-S.; Xu, J.-M.; Qin, X.-Y.; Chen, C.-Z.; Li, R.-C.; Hou, Y.-Y. Assessment of T Staging and Mesorectal Fascia Status Using High-Resolution MRI in Rectal Cancer with Rectal Distention. World J Gastroenterol 2007, 13 (30), 4141–4146. https://doi.org/10.3748/wjg.v13.i30.4141.
11. Beets-Tan, R. G.; Beets, G. L.; Vliegen, R. F.; Kessels, A. G.; Van Boven, H.; De Bruine, A.; von Meyenfeldt, M. F.; Baeten, C. G.; van Engelshoven, J. M. Accuracy of Magnetic Resonance Imaging in Prediction of Tumour-Free Resection Margin in Rectal Cancer Surgery. Lancet 2001, 357 (9255), 497–504. https://doi.org/10.1016/s01406736(00)04040-x.
12. Brown, G.; Radcliffe, A. G.; Newcombe, R. G.; Dallimore, N. S.; Bourne, M. W.; Williams, G. T. Preoperative Assessment of Prognostic Factors in Rectal Cancer Using High-Resolution Magnetic Resonance Imaging. Br J Surg 2003, 90 (3), 355–364. https://doi.org/10.1002/bjs.4034.