cerebral artery stenosis, cerebral artery occlusion, MRI...
Main Article Content
Abstract
Objective: This study aims to describe the characteristics of cerebral
artery stenosis on MRI and the relationship with some risk factors and
causes of cerebral artery stenosis.
Method: Cross-sectional descriptive study from 104 patients with
images of intracranial artery stenosis using 3T MRI, from June 2021 to
June 2022 at Bach Mai hospital, Hanoi, Vietnam.
Results: The average age is 64.71 ± 14.08, the age group ≥60
accounts for the highest proportion of 76%, the male/female ratio is ~
2.58:1. 27 patients (26%) had from two or more narrowing arteries. Stenosis
is common in the anterior circulation (66.4%), the ratio posterior/anterior
circulation ~ 2:1. ICA and MCA are the most affected (33,6% & 29,3%,
respectively), ACA is the least affected (3,6%). In anterior circulation,
moderate stenosis accounts for the highest rate (33.6%; p=0.008), arterial
occlusion is relatively high in cases of stenosis in the posterior circulation
(38.2%; p= 0.409). Eccentric stenosis is the highest (79/140; 56.4%),
followed by occlusion (39/140, 27.8%), concentric stenosis (22/140;
15.8%) (p =0.135). Among risk factors, arterial hypertension increases the
rate of stenosis by 2,840 times (p = 0.031, 95% CI [1,099;7,340]) and the
rate of atherosclerosis by 3,102 times (p = 0.012), 95% CI [1.254;7.675]).
Atherosclerosis is the main cause of arterial stenosis and occlusion
(0.52%); followed by the undetermined cause (19.3%), vasospasm (15%),
and MoyaMoya (5.7%). Brain parenchymal damage has the highest rate in
stenosis and occlusion due to atherosclerosis (74%, p < 0.05).
Conclusion: Cerebral vascular stenosis is common in the anterior
circulation, mainly in the ICA and MCA. Atherosclerosis is a common cause
of cerebral artery stenosis in both the anterior and posterior circulation.
Arterial hypertension is a risk factor for cerebral artery stenosis.
Keywords
cerebral artery stenosis, cerebral artery occlusion, MRI...
Article Details
References
2. Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. Int J Stroke. 2022;17(1):18-29. doi:10.1177/17474930211065917
3. Stroke Mechanisms in Symptomatic Intracranial Atherosclerotic Disease | Stroke. Accessed June 28, 2024. https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.025732
4. Embolic strokes of undetermined source: the case for a new clinical construct - The Lancet Neurology. Accessed June 28, 2024. ttps://www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70310-7/abstract
5. Holmstedt CA, Turan TN, Chimowitz MI. Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment. Lancet Neurol. 2013;12(11):1106-1114. doi:10.1016/S1474-4422(13)70195-9
6. Han Y, Qiao H, Chen S, et al. Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design. Brain Behav. 2018;8(12):e01154. doi:10.1002/brb3.1154
7. Frontiers | A High-Resolution MRI Study of the Relationship Between Plaque Enhancement and Ischemic Stroke Events in Patients With Intracranial Atherosclerotic Stenosis. Accessed June 29, 2024. https://www.frontiersin.org/ journals/neurology/articles/10.3389/fneur.2018.01154/full
8. The intrinsic signal-to-noise ratio in NMR imaging - PubMed. Accessed June 29, 2024. https://pubmed.ncbi.nlm. nih.gov/3747821/
9. Samuels OB, Joseph GJ, Lynn MJ, Smith HA, Chimowitz MI. A standardized method for measuring intracranial arterial stenosis. AJNR Am J Neuroradiol. 2000;21(4):643-646.
10. The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patients - PubMed. Accessed June 29, 2024. https://pubmed.ncbi.nlm.nih.gov/10471419/
11. Zhang K, Ren W, Li TX, et al. Sub-satisfactory recanalization of severe middle cerebral artery stenoses can significantly improve hemodynamics. Front Cardiovasc Med. 2022;9. doi:10.3389/fcvm.2022.922616
12. Hua Y, Jia L, Xing Y, et al. Distribution Pattern of Atherosclerotic Stenosis in Chinese Patients with Stroke: A Multicenter Registry Study. Aging Dis. 2019;10(1):62-70. doi:10.14336/AD.2018.0602
13. Sun Q, Wang Q, Wang X, et al. Prevalence and cardiovascular risk factors of asymptomatic intracranial arterial stenosis: the Kongcun Town Study in Shandong, China. Eur J Neurol. 2020;27(4):729-735. doi:10.1111/ene.14144
14. Sun P, Liu L, Pan Y, et al. Intracranial Atherosclerosis Burden and Stroke Recurrence for Symptomatic Intracranial Artery Stenosis (sICAS). Aging Dis. 2018;9(6):1096-1102. doi:10.14336/AD.2018.0301
15. Weber R, Kraywinkel K, Diener HC, Weimar C, German Stroke Study Collaboration. Symptomatic intracranial atherosclerotic stenoses: prevalence and prognosis in patients with acute cerebral ischemia. Cerebrovasc Dis Basel Switz. 2010;30(2):188-193. doi:10.1159/000317107
16. Zhao J, Li X, Chi LX, et al. Concomitant Asymptomatic Intracranial Atherosclerotic Stenosis Increase the 30- Day Risk of Stroke in Patients Undergoing Symptomatic Intracranial Atherosclerotic Stenosis Stenting. J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. 2018;27(2):479-485. doi:10.1016/j.jstrokecerebrovasdis.2017.09.032
17. Wong LKS. Global burden of intracranial atherosclerosis. Int J Stroke Off J Int Stroke Soc. 2006;1(3):158-159. doi:10.1111/j.1747-4949.2006.00045.x
18. Bae HJ, Lee J, Park JM, et al. Risk factors of intracranial cerebral atherosclerosis among asymptomatics. Cerebrovasc Dis Basel Switz. 2007;24(4):355-360. doi:10.1159/000106982
19. Munio M, Darcourt J, Gollion C, Barbieux-Guillot M, Bonneville F, Larrue V. Large artery intracranial stenosis in young adults with ischaemic stroke. Rev Neurol (Paris). 2022;178(3):206-212. doi:10.1016/j.neurol.2021.10.008
20. Moyamoya: An Update and Review - PubMed. Accessed June 30, 2024. https://pubmed.ncbi.nlm.nih.gov/33209550/