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Date Published: 14/01/2025
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DOI: https://doi.org/10.55046/vjrnm.57.1300.2024
Issue
No. 57 (2024)
Section
Scientific research
How to Cite
Hoang, N. T., Dang, C. N., Nguyen, T. T., L, T. B., & Trần, H. P. D. (2024). EFFICACY OF APPARENT DIFFUSION COEFFICIENT METRIC IN MRI DIFFUSION FOR BENIGN AND MALIGNANT LESION DISCRIMINATION. Vietnamese Journal of Radiology and Nuclear Medicine, 57, 67-76. https://doi.org/10.55046/vjrnm.57.1300.2024

EFFICACY OF APPARENT DIFFUSION COEFFICIENT METRIC IN MRI DIFFUSION FOR BENIGN AND MALIGNANT LESION DISCRIMINATION

Hoang Ngoc Thanh1, Dang Cam Nhung1, Nguyen Thanh Thao1, Le Trong Binh1, Hồng Phương Dung Trần2,
1 Department of Diagnostic Imaging, University of Medicine and Pharmacy, Hue University
2 Bộ môn Chẩn đoán hình ảnh, Đại học Y Dược, Đại học Huế

Main Article Content

Abstract

Objective: The primary aim was to assess the efficacy of using Apparent Diffusion Coefficient (ADC) ratios, in differentiating between benign and malignant liver lesions.


Methodology: A descriptive cross-sectional study in 69 patients was conducted from January 2023 to December 2023. Liver lesions were classified as benign or malignant based on radiological features, histopathological findings, and biochemical tests. Participants underwent standard MRI scans on Siemens 1.5-Tesla scanners using conventional sequences and diffusion sequences with b=50, b=400, b=800s/mm2.


Results: The dataset comprised 20 benign and 49 malignant lesions, median age 57 ± 14 years, male/female ratio 1.65. The average lesion to liver ADCratio1 and average lesion to spleen ADCratio2 of benign lesions were significantly higher than those of malignant lesions, 1.86 vs. 1.05 and 2.25 vs. 1.47, p < 0.001, respectively. Optimal cut-off values for ADCratio 1 and ADCratio 2 to differentiate between benign and malignant lesions were 1.17 and 1.66, respectively, resulting in sensitivities of 95% and 85%, and specificities of 75.5% and 77.5%, respectively.


Conclusion: This study demonstrates significant differences in ADC ratios between benign and malignant solid liver lesions, establishing specific cut-off values with high sensitivity and specificity for differentiation.


Keywords: Diffusion-weighted imaging (DWI), Apparent diffusion coefficient (ADC), Apparent diffusion coefficient ratio. (ADCratio), Liver lesion, Benign, Malignant.


Abbreviations: CCC: cholangiocarcinoma; FNH: focal nodular hyperplasia; HCC: hepatocellular carcinoma; MRI: magnetic resonance imaging; DWI: diffusion weighted imaging; ADC: apparent diffusion coefficient; ROI: region of interest; ROC: receiver operating characteristic

Keywords

Diffusion-weighted imaging (DWI),, Apparent diffusion coefficient (ADC), Apparent diffusion coefficient ratio, (ADCratio), Liver lesion, Benign, Malignant.

Article Details

References

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