Article Sidebar

pdf
Date Published: 09/02/2026
Abstract Views: 0
Views pdf: 0
DOI: https://doi.org/10.55046/vjrnm.61.1457.2025
Issue
No. 61 (2025)
Section
Scientific research
How to Cite
Lê, T. T. H., Nguyễn, Q. A., Nguyễn, T. T. T., & Vũ, Đ. L. (2025). Comparison of Computed Tomography Characteristics between Pulmonary Adenocarcinoma and Squamous Cell Carcinoma at Bach Mai Hospital. Vietnamese Journal of Radiology and Nuclear Medicine, 61, 12-20. https://doi.org/10.55046/vjrnm.61.1457.2025

Comparison of Computed Tomography Characteristics between Pulmonary Adenocarcinoma and Squamous Cell Carcinoma at Bach Mai Hospital

Thị Thanh Hạnh Lê1, , Quang Anh Nguyễn1, Thị Thu Thảo Nguyễn2, Đăng Lưu Vũ1
1 Trường Đại học Y Hà Nội
2 Bệnh viện Bạch Mai

Main Article Content

Abstract

Objective: To compare the CT imaging features of lung adenocarcinoma and squamous cell carcinoma.


Methods: This was a descriptive cross-sectional and retrospective study conducted on 407 patients diagnosed with lung adenocarcinoma or squamous cell carcinoma confirmed by histopathology. All patients underwent chest CT scans between January 2022 and July 2024 at Bach Mai Hospital. Imaging characteristics analysed included tumour size, density, margin, calcification, cavitation, anatomical location, bronchial involvement, and invasion of adjacent structures, alongside epidemiological features such as age and sex. Data were processed using SPSS version 20.0.


Results: Adenocarcinomas were predominantly located peripherally (43.8%). Squamous cell carcinomas were more frequently central (43.2%), had a larger mean tumour size (48.5 mm vs. 39.7 mm), a higher rate of bronchial invasion (15.9%), and a higher proportion of male patients (86.4%). No statistically significant differences were observed between the two groups regarding lobar location, tumour margin, calcification.


Conclusion: CT imaging can delineate several features that help distinguish between the two histological types, thereby aiding in diagnostic orientation and the development of an appropriate treatment plan.

Keywords

lung adenocarcinoma, lung squamous cell carcinoma, computed tomography

Article Details

References

1. F. Bray, M. Laversanne, H. Sung, J. Ferlay, R. L. Siegel, I. Soerjomataram, and A. Jemal (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 74(3),229–263.
2. Y. Wang, S. Zou, Z. Zhao, P. Liu, C. Ke, and S. Xu (2020). New insights into small-cell lung cancer development and therapy. Cell Biology International, 44(8),1564–1576.
3. B. R. Sabbula, D. P. Gasalberti, S. K. R. Mukkamalla, and F. Anjum (2025). Squamous Cell Lung Cancer.
4. H. Shigematsu, L. Lin, T. Takahashi, M. Nomura, M. Suzuki, I. I. Wistuba, K. M. Fong, H. Lee, S. Toyooka, N. Shimizu, T. Fujisawa, Z. Feng, J. A. Roth, J. Herz, J. D. Minna, and A. F. Gazdar (2005). Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. Journal of the National Cancer Institute, 97(5),339–346.
5. F. J. Fintelmann, A. Bernheim, S. R. Digumarthy, I. T. Lennes, M. K. Kalra, M. D. Gilman, A. Sharma, E. J. Flores, V. V. Muse, and J.-A. O. Shepard (2015). The 10 Pillars of Lung Cancer Screening: Rationale and Logistics of a Lung Cancer Screening Program. Radiographics: A Review Publication of the Radiological Society of North America, Inc, 35(7),1893–1908.
6. M. Paśnik, I. Bestry, and K. Roszkowski-Śliż (2017). Solitary pulmonary nodule - the role of imaging in the diagnostic process. Advances in Respiratory Medicine, 85(6),345–351.
7. A. A. Bankier, H. MacMahon, J. M. Goo, G. D. Rubin, C. M. Schaefer-Prokop, and D. P. Naidich (2017). Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society. Radiology, 285(2),584–600.
8. M. Gaeta, I. Pandolfo, S. Volta, E. G. Russi, G. Bartiromo, G. Girone, F. La Spada, M. Barone, G. Casablanca, and A. Minutoli (1991). Bronchus sign on CT in peripheral carcinoma of the lung: value in predicting results of transbronchial biopsy. AJR. American journal of roentgenology, 157(6),1181–1185.
9. Ngô Tuấn Minh, Lê Vũ Duy, Nguyễn Xuân Phùng, Đỗ Xuân Hiền (2018). Đặc điểm hình ảnh cắt lớp vi tính lồng ngực của bệnh nhân ung thư phổi typ biểu mô tuyến. Tạp chí Y Dược học Quân sự, 43(1), 85-90.
10. Ngô Tuấn Minh, Lê Vũ Duy, Lê Thị Hồng Vân, Nguyễn Tiến Dũng (2018). Đặc điểm hình ảnh cắt lớp vi tính lồng ngực của bệnh nhân ung thư phổi typ biểu mô tế bào vảy. Tạp chí Y Dược học Quân sự, 43(3), 85-90.
11. H. S. Gharraf, S. M. Mehana, and M. A. ElNagar (2020). Role of CT in differentiation between subtypes of lung cancer; is it possible? The Egyptian Journal of Bronchology, 14(1),28.
12. J.-Y. Yue, J. Chen, F.-M. Zhou, Y. Hu, M.-X. Li, Q.-W. Wu, and D.-M. Han (2018). CT-pathologic correlation in lung adenocarcinoma and squamous cell carcinoma. Medicine, 97(50),e13362.
13. Cung Văn Công (2015). Nghiên cứu đặc điểm hình ảnh cắt lớp vi tính đa dãy đầu thu ngực trong chẩn đoán ung thư phối nguyên phát ở người lớn, Luận án Tiến sĩ Y học, Viện nghiên cứu Khoa học Y Dược Lâm sàng 108.
14. W. D. Travis, E. Brambilla, M. Noguchi et al (2011). International association for the study of lung cancer/american thoracic society/european respiratory society international ultidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer, 6(2),244–285.
15. C. M. Ciofiac, M. Mămuleanu, L. M. Florescu, and I. A. Gheonea (2024). CT Imaging Patterns in Major Histological Types of Lung Cancer. Life (Basel, Switzerland), 14(4),462.
16. Y. Kunihiro, T. Kobayashi, N. Tanaka, T. Matsumoto, M. Okada, M. Kamiya, K. Ueda, H. Kawano, and N. Matsunaga (2016). High-resolution CT findings of primary lung cancer with cavitation: a comparison between adenocarcinoma and squamous cell carcinoma. Clinical Radiology, 71(11),1126–1131.