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Date Published: 09/02/2026
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DOI: https://doi.org/10.55046/vjrnm.61.1483.2025
Issue
No. 61 (2025)
Section
Medical Forum
How to Cite
Nguyễn, T. K. H., Đàm, T. T., Phạm, M. C., Vũ, Đ. L., & Nguyễn, Q. A. (2025). Langerhans Cell Tumor of the Spine: A Report of Two Clinical Cases. Vietnamese Journal of Radiology and Nuclear Medicine, 61, 79-84. https://doi.org/10.55046/vjrnm.61.1483.2025

Langerhans Cell Tumor of the Spine: A Report of Two Clinical Cases

Thị Kim Huệ Nguyễn1, , Thủy Trang Đàm2, Mạnh Cường Phạm2, Đăng Lưu Vũ2, Quang Anh Nguyễn1
1 Trường Đại học Y Hà Nội
2 Hội Điện quang và Y học hạt nhân Việt Nam

Main Article Content

Abstract

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the abnormal proliferation of Langerhans-like cells, with potential involvement of multiple organs. The skeletal system is the most commonly affected site, accounting for approximately 60–80% of cases, with spinal involvement reported in 6.5–25% of cases and associated with a high risk of severe neurological complications. Imaging plays a crucial role in the detection and characterization of lesions, with hallmark features including “vertebra plana,” lytic bone lesions with or without associated soft-tissue masses, and characteristic signal alterations on MRI. However, due to overlapping features with infectious and malignant conditions, histopathological biopsy remains the gold standard for definitive diagnosis.

Keywords

Langerhans cell histiocytosis, Bone lesions, Spinal lesions, Diagnostic imaging.

Article Details

References

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