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Value of mri with gadoxetic acid (primovist) for diagnosing hepatocellular carcinoma
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Abstract
Aim: Evaluate the value of MRI with Gd-EOB-DTPA (Primovist) in the detection of HCC comparison with the pathological results
Methods: Descriptive cross-sectional research, performed on 28 patients consist of 2 groups: Group I includes 18 patients with HCC and group II includes 10 non-HCC patients (7 patients with focal nodular hyperplasia. 3 patients with liver metastasis). The patients whose liver lesion were detected on diagnostic imaging modalities undergone MRI with hepatiobillial specific contrast agent Gd-EOB-DTPA (Primovist). Thereafter, definite diagnosis was based on histopathological results of biopsy or surgery.
Results: Hepatobiillial phase hypointense was the most sensitive diagnostic criteria of HCC(94.4%), however, specificity is only 70%. For liver cancer diagnosing, arterial enhancement followed by washout on portal venous or late phase had the sensitivity, negative predictive value and diagnostic accuracy were 61.1%, 58.8% and 75%, respectively. When combining with hepatobillial phase hypointense, these values increased to 72.2%, 67.7%, and 82.1%, respectively; while, the specificity and positive predictive values were unchanged.
Conclusion: Hepatobiillial phase hypointense is a good diagnostic criteria on detection of HCC than differential diagnosis with other hepatic lesions. The addition of hepatobiillial phase on MRI with Gd-EOB-DTPA (Primovist) increases the likelihood of detecting HCC lesions
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