SỰ ĐÓNG GÓP TO LỚN CỦA Y HỌC HẠT NHÂN QUA XẠ HÌNH GEN VÀ PHÂN TỬ

Abstract

SUMMARY

Molecular imaging provides visualization of normal as well as abnormal cellular processes at a molecular or genetic level rather than at the anatomical level. In a narrow sense, molecular imaging means genetic imaging using imaging reporter genes. Conventional PET imaging reporter genes, such as HSV1-tk, and D2R are quite successful. Some investigators have tried to use scintigraphy for molecular imaging. Endogenous gene expressions such as p53 and HIF1-alpha have been visualized using this technique. The molecular imaging using the NIS gene can be applied to the monitoring in vivo distributions of target cells, such as cancer cells, immune cells and stem cells. These peptides can localize cancers in vivo (Peptide Receptor Radiation Scintigraphy: PRRS) and treat cancers (Peptide Receptor Radiation Therapy: (PRRT).The development of PET/CT has led to genomic and preteomic imaging techniques to have a leading role in in vivo studies for evaluation and management of cardiovascular disease conditions. Molecular imaging plays also an increasingly significant role in neurological conditions such as: tumors, dementias (Alzheimer’s and others), movement disorders, seizure disorders, and psychiatric disorders. PET/CT has also many advantages in the process of creating new medicines through the process of evaluating the pharmacokinetics (pharmacokinetics and pharmacodynamics).