Article Sidebar
Views PDF: 68
Skull metastasis arising from pulmonary squamous cell carcinoma: A case report
Main Article Content
Abstract
SUMMARY
Introduction: Squamous cell carcinoma of the lung represents 30% of all non-small cell lung carcinomas. It arises from dysplasia of squamous epithelium of the bronchi and is strongly associated with cigarette smoking. Squamous cell carcinoma of the lung is known to produce metastases in the brain parenchyma.
Case presentation: We present the case of a 77-year-old woman with an unusual presentation of metastatic carcinoma of the lung. The case demonstrated a squamous cell carcinoma of the lung with an intracranial metastatic lesion destroying the parietal bone and extending into the extra cranial soft tissue. A visible deformity as a result of the metastasis was evident on physical examination, magnetic resonance imaging and computed tomography demonstrated extensive bone destruction.
Conclusion: Squamous cell carcinoma of the lung with an intracranial metastatic lesion is rare in the world literature. The case report demonstrates an unusual disease presentation with an intra-cranial metastasis invading through the skull.
Article Details
Keywords
Destruction of bone, Metastasis, Squamous cell carcinoma
References
1. Foco F, Dizdarevic-Spago D, Efendic R, Dizdarevic D, Babajic E, Sarajlic L: Adenocarcinoma
metastaticum of the frontal region. Med Arh 2011, 65:61- 62.
2. Groome P, Bolejack V, Crowley J, Kennedy C, Krasnik M, Sobin L, Goldstraw P: The IASLC lung cancer staging project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007, 2:694.
3. Healy J, Marshall W, Brahme F, White F: CT of intracranial metastases with skull and scalp involvement. Am J Neuroradiol 1981, 2:335-336.
4. Kader. I,Strong. M, George. M.. Skull destruction from intracranial metastasis arising from pulmonary squamous cell carcinoma: a case report. Journal of Medical Case Reports 2013, 7:28.
5. Lê Trung Thọ. Nghiên cứu Y học: Chẩn đoán tế bào học một số ung thư phế quản. Chuyên đề Giải Phẫu bệnh. Tế bào bệnh học 17. Y Học TP. Hồ Chí Minh. Tập 11. Phụ bản Số 3-2007.
6. Meyers C: Neurocognitive dysfunction in cancer patients. Oncology (Huntington) 2000, 14:75- 79.
7. Nair A, Klusmann M, Jogeesvaran K, Grubnic S, Green S, Vlahos I: Revisions to the TNM staging of non-small cell lung cancer: rationale,
clinicoradiologic implications, and persistent limitations. RG 2011, 31:215-238.
8. Ngô Thế Quân, Phạm Thị Thái Hà, Nguyễn Chi Lăng, Nguyễn Công Định. Phân loại mô bệnh học ung thư phế quản. Theo phân loại của WHO-1999. Chuyên đề Giải Phẫu bệnh. Tế bào bệnh học 17. Y Học TP. Hồ Chí Minh. Tập 11. Phụ bản Số 3-2007.
9. Nonaka D: A study of ΔNp63 expression in lung non-small cell lung carcinomas. Am J Surg Pathol 2012, 36:895-899.
10. Okamoto M, Hiura K, Ohe G, Ohba Y, Terai K, Oshikawa T, Furuichi S, Nishikawa H, Moriyama K, Yoshida H, Sato M: Mechanism for bone invasion of oral cancer cells mediated by interleukin-6 in vitro and in vivo. Cancer 2000, 89:1966-1975.
11. Perez-Moreno P, Brambilla E, Thomas R, Soria J: Squamous cell carcinoma of the lung: molecular subtypes and therapeutic opportunities. Clin Cancer Res 2012, 18:2443-2451.
12. Platta C, Khuntia D, Mehta M, Suh J: Current treatment strategies for brain metastasis and complications from therapeutic techniques: a review of current literature. Am J Clin Oncol 2010, 33:398-407.
13. Roato I, Caldo D, Godio L, D’Amico L, Giannoni P, Morello E, Quarto R, Molfetta L, Buracco P, Mussa A, Ferracini R: Bone invading NSCLC cells produce IL-7: mice model and human histologic data. BMC Cancer 2010, 10:12.
14. Rossi G, Marchioni A, Sartori G, Longo L, Piccinini S, Cavazza A: Histotype in non-small cell lung cancer therapy and staging: the emerging role of an old and underrated factor. Curr Respir Med Rev 2007, 3:69- 77.
15. Ruysscher D, Wanders R, Baardwijk A, Dingemans A, Reymen B, Houben R, Bootsma G, Pitz C, Eijsden L, Geraedts W, Baumert B, Lambin
P: Radical treatment of non-small-cell lung cancer patients with synchronous oligometastases: longterm results of a prospective phase II trial. J Thoracic Oncol 2012, 7:1547-1555.
16. Schellinger P, Meinck H, Thron A: Diagnostic accuracy of MRI compared to CCT in patients with brain metastases. J Neurooncol 1999, 44:275-281.
17. Soffietti R, Ruda R, Trevisan E: Brain metastases: current management and new developments. Curr Opin Oncol 2008, 20:676-684.
18. Sohara Y, Shimada H, DeClerck Y: Mechanisms of bone invasion and metastasis in human neuroblastoma. Cancer Lett 2005, 228:203- 209.
19. Tachasuttirut K, Hasegawa S, Yoshino N, Ito D, Omura K: Effect of irradiation on malignant tumour invasion into bone. Asian J Oral Maxillofac Surg 2008, 20:117-123.
20. Turgut M, Colak A, Gurcay O: Multiple intracranial metastases with skull and scalp involvement in Ewing’s sarcoma. Cent Afr J Med 1994, 40:104-106.
21. Vogelbaum M, Suh J: Resectable brain metastases. J Clin Oncol 2006, 24:1289-1294.