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Date Published: 08/07/2022
Online Published: 08/07/2022
Abstract Views: 338
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DOI: https://doi.org/10.55046/vjrnm.35.604.2019
Issue
No. 35 (2019)
Section
Scientific research
How to Cite
Bui, Q. B., Le, N. H., & Lam, K. (2022). Imaging characteristics and diagnostic value of 18F-FDG PET/CT in post-operative differentiated thyroid cancer patients with elevated serum thyroglobulin and negative 131I whole body scan. Vietnamese Journal of Radiology and Nuclear Medicine, 35, 59-67. https://doi.org/10.55046/vjrnm.35.604.2019

Imaging characteristics and diagnostic value of 18F-FDG PET/CT in post-operative differentiated thyroid cancer patients with elevated serum thyroglobulin and negative 131I whole body scan

Bui Quang Bieu1, Le Ngoc Ha1, Lam Khanh1,
1 Military Central Hospital 108

Main Article Content

Abstract

SUMMARY


To evaluate the imaging characteristics and diagnostic value of 18F-FDG PET/CT in post-operative differentiated thyroid cancer (DTC) patients with elevated serum thyroglobulin and negative 131I whole body scan.
Materials and method: we performed a cross-sectional descriptive study on 109 post-surgical DTC patients. All patients underwent 18F-FDG
PET/CT scan to look for recurrence/metastasis. PET/CT results were compared with hisopathology and clinical follow-up to determine its diagnostic values.
Results: 294 lesions were identified in PET/CT with mean diameter and SUV were 14.0 mm và 9.3 g/ml, respectively. Lesions were most found in
cervical lymphnode, mediastinum, thyroid bed and lung. PET/CT was positive in 78% of patients with true positive, false positive, true negative and false negative rates were 92.9; 7.1; 75 and 25%; respectively. Sensitivity, specificity
and accuracy of PET/CT in detecting recurrent/metastatic DTC were 92.9; 75
and 89%, respectively. SUVmax threshold of 5.9 ng/ml was the most suitable to determine recurrent/metastatic lesions in PET/CT.
Conclusions: 18F-FDG PET/CT is a valuable imaging tool to diagnose recurrence/metastasis in DTC patient with elevated serum thyroglobulin and negative 131I whole body scan.

Article Details

Keywords

18F-FDG PET/CT, differentiated thyroid cancer, elevated thyroglobulin, negative131I whole body scan

References

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