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The correlation between apparent diffusion coefficient and immunohistological marker ki-67 in the preoperative grading of glioma
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Abstract
SUMMARY
Purpose: To study the correlation between apparent
diffusion coefficient (ADC) and immunohistological marker Ki-67 in the preoperative grading of glioma.
Materials and methods: cMRI, DWI were preoperatively
performed in 15 patients with pathologically confirmed gliomas and Ki67 was done in Choray hospital from 1/2015 to 1/2016. The ADC value were measured at tumortissue (ADCt) and contralateral normal brain (ADCc). ADCn were calculated by divided ADCt to ADCn. Ki67 were calculated semi quantitatively. Grade of gliomas were divided to low and high gradegroup. The correlation between ADC values and Ki67 in the grade gliomas were analyzed.
Results: The ADCt, ADCn values of high-grade gliomas
were significantly lower than those of low-grade gliomas (1156.48 mm2/s and 744.26 mm2/s, p=0.036). The ADCt, ADCn values of tumor parenchyma were negatively correlated with the degree of malignancy of the gliomas(r=-0.567,p=0.028). The Ki-67 labeling index was significantly positive correlation with the degree of
malignancy of the gliomas (r=1, p=0.00). The Ki-67 labeling index was negatively correlated with the ADCt and ADCn values in the grading of glioma (r =-0.515; p=0.049 and r =-0.567, p=0.028).
Conclusion: The ADC values of tumor and the Ki-67 labeling index were negatively correlated in the grading of glioma.The ADC values were negatively correlated and the Ki-67 labeling index were positively correlated in the grading of glioma.
Article Details
Keywords
Diffusion weighted imaging (DWI), apparent diffusion coefficient (ADC), immunohistological marker, Ki-67, correlation, grade, gliomas
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