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Date Published: 11/07/2022
Online Published: 11/07/2022
Abstract Views: 98
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DOI: https://doi.org/10.55046/vjrnm.25.639.2016
Issue
No. 25 (2016)
Section
Scientific research
How to Cite
Hoang, D. H., & Alexandre, . K. (2022). MRI imaging and cognitive disorders in children treated for cerebellar medulloblastoma. Vietnamese Journal of Radiology and Nuclear Medicine, 25, 39-45. https://doi.org/10.55046/vjrnm.25.639.2016

MRI imaging and cognitive disorders in children treated for cerebellar medulloblastoma

Dr Hoang Duc Ha1, Dr Alexandre Krainik2
1 Faculty of College of Medicine - Hospital Hai Phong Viet Tiep Friendship
2 College of Neurology - Institute of Medicine Grenoble School - France

Main Article Content

Abstract

Objective: Neurocognitive impairment occurs commonly in children treated for medulloblastoma, affecting their quality of life
and school performance. The aim of this study was to investigate the involvement of the cerebellum in neurocognitive disorders observed in these children.
Material and methods: In this study, 12 children (7 males, 5 females, mean age 13,0±1,6 years) treated for cerebellar
medulloblastoma and 18 age-matched control children were recruited to perform neuropsychological tests. All subjects were
native French speakers, right-handed, with a global intelligence quotient (IQ) of 70-130. Structural MRI and SUIT model (spatially unbiased infratentorial and cerebellar template) were used to show the position of resected lesions in the patient group. Neuropsychological data were analyzed by using a Mann- Whitney U test.
Results: Patient group had cognitive impairments including visuospatial performance (6/12 patients), verbal memory (1/12
patients), processing speed (4/12 patients). Patients with resected lesions in the left posterior lobe of the cerebellum (7/12 patients) suffered from visuospatial memory impairment (6/7 patients).
Conclusion: In conclude, this study provides further evidence that the cerebellum plays a role in working memory.
The left posterior cerebellar lobe may be involved in children’s visuospatial working memory.

Article Details

Keywords

Children, Medulloblastoma, Working Memory, cerebellar MRI

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