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Abstract
Objectives: Determine the mean SULmax level of the tumor in cervical cancer and compare the SULmax level between different histological types. Determine the mean size and mean SULmax level of metastatic lymph nodes in cervical cancer. Determine the percentage of cervical cancer patients with stage change after PET/CT imaging. Determine the rate of accidental distant metastases detected by PET/CT.
Subjects and research methods: 37 cervical cancer patients underwent PET/CT scan at Ho Chi Minh City Oncology Hospital from January 2020 to November 2021, the purpose of PET/CT scan is pre-treatment staging.
Result: The mean SULmax of the primary tumor in cervical cancer was 13,88. The mean SULmax of squamous cell carcinoma and adenocarcinoma was quite similar and much higher than that of small cell carcinoma. Tumors of the squamous cell carcinoma had the highest mean SULmax. The mean size of metastatic lymph nodes in cervical cancer was 20,79 mm with a mean SULmax of 10,72. 48.6% of cervical cancer patients had stage transition after PET/CT imaging. In which, 35.1% of patients increased stage and 13.5% of patients decreased stage. The rate of newly discovered distant metastasis was 27%, the most common site of newly discovered distant metastasis was in the supraclavicular lymph nodes.
Conclusion: Malignant neoplasms of the cervix have a high uptake for 18F-FDG, with the mean SULmax of the primary tumor often being very high. Squamous cell carcinoma has the highest SULmax uptake of all histological types, but still needs to be investigated with a larger number of patients. Nodal metastases in cervical cancer also have a high uptake for 18F-FDG. Nearly half of cervical cancer patients have stage change after PET/CT imaging. Most of the cases of patients increased stage due to newly discovered distant metastatic lesions after PET/CT in the group of patients with stage IIIC1r, IIIC2r. This shows that the clinical practice on indications for PET/CT scans currently being applied at the Department of Gynecological Radiation and Oncology Hospital in Ho Chi Minh City is very practical and useful.
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References
2. Grigsby PW, Siegel BA, Dehdashti F. Lymph node staging by PET in patients with carcinoma of the cervix. J Clin Oncol 2001; 19:3745–3749
3. Lee JH, Kim J, Moon HJ, et al. Supraclavicular lymph nodes detected by 18F-FDG PET/CT in cancer patients: assessment with 18F-FDG PET/CT and sonography. AJR 2012; 198:187–193
4. Wong TZ, Jones EL, Coleman RE. Positron emission tomography with 2-deoxy-2-[(18)F] fluoro-D-glucose for evaluating local and distant disease in patients with cervical cancer. Mol Imaging Biol 2004; 6:55–62.
5. Revisiting Weight-Normalized SUV and Lean-Body-Mass-Normalized SUV in PET Studies; 10.2967/ jnmt.119.233353
6. Sala E, Wakely S, Senior E, Lomas D. MRI of malignant neoplasms of the uterine corpus and cervix. AJR 2007; 188:1577–1587
7. Loft A, Berthelsen AK, Roed H, et al. The diagnostic value of PET/CT scanning in patients with cervical cancer: a prospective study. Gynecol Oncol 2007; 106:29–34
8. Murakami R, Uozumi H, Hirai T, Nishimura R, Shiraishi S, Ota K, et al. Impact of FDG-PET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2007;68(2):377–82
9. Bryant AS, Cerfolio RJ, Klemm KM, Ojha B. Maximum standard uptake value of mediastinal lymph nodes on integrated FDG-PET-CT predicts pathology in patients with non-small cell lung cancer. Ann Thorac Surg. 2006;82(2):417–22. discussion 22–3.
10. Ela Bella AJ, Zhang YR, Fan W, Luo KJ, Rong TH, Lin P, et al. Maximum standardized uptake value on PET/CT in preoperative assessment of lymph node metastasis from thoracic esophageal squamous cell carcinoma. Chin J Cancer. 2014;33(4):211–7