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Date Published: 28/02/2023
Online Published: 03/03/2023
Abstract Views: 268
Views PDF: 206
DOI: https://doi.org/10.55046/vjrnm.50.682.2023
Issue
No. 50 (2023)
Section
Scientific research
How to Cite
Nguyễn, T. P., Mai, H. S., Nguyen, T. N., Le, D. H., Nguyen, T. T. N., & Le, N. H. (2023). The relationship between thyroglobulin, thyroglobulin doubling time and recurrent/metastatic lesions detected in 18F-FDG PET/CT in radioiodine refractory differentiated thyroid cancer. Vietnamese Journal of Radiology and Nuclear Medicine, 50, 61-69. https://doi.org/10.55046/vjrnm.50.682.2023

The relationship between thyroglobulin, thyroglobulin doubling time and recurrent/metastatic lesions detected in 18F-FDG PET/CT in radioiodine refractory differentiated thyroid cancer

Thị Phương Nguyễn1,, Mai Hong Son2, Nguyen Thi Nhung2, Le Duy Hung2, Nguyen Thi Tuyet Nhung3, Le Ngoc Ha2
1 Khoa Y học hạt nhân - Bệnh viện TƯQĐ 108
2 Military Central Hospital 108
3 Hospital 198

Main Article Content

Abstract

The relationship between thyroglobulin, thyroglobulin doubling time and recurrent/metastatic lesions detected in 18F-FDG PET/CT in radioiodine refractory differentiated thyroid cancer


Abstract


Background: 18F-FDG PET/CT is method with high sensitivity and specificity in the diagnosis of recurrent lesions in patients with radioiodine refractory differentiated thyroid cancer ((RAI-R- DTC). The aim of this study was to evaluate the relationship between Tg, Tg – DT and rucurrent/metastatic lessions detected in 18F-FDG PET/CT imaging in RAI-R DTC patients.


Methods: 119 RAI-R DTC patients underwent 18F-FDG PET/CT. At least two consecutive Tg measurements under the thyroid hormone replacement therapy (TSH ≤ 0,1 uIU/ml) to calculate Tg - DT before 18F-FDG PET/CT scan. We analyzed the relationship between PET/CT imaging and clinical characteristics, risk of recurrence, Tg and Tg – DT.


Results: 18F-FDG PET/CT imaging detected recurrent lesions in 88 patients (73,9 %) and distant metastasis in 29 patient (24,3 %). Tg-DT was significantly lower in the positive PET/CT group compared to negative PET/CT group (median 12.9 vs 166 months, p< 0.001). Serum Tg concentration in the patients with distant metastasis was higher than those without distant metastasis (334 ng/ml vs 114.6 ng/ml, p < 0.001). In univariate and multivariate logistic regression analysis, Tg-DT was an independent predictor of positive PET/CT and serum Tg concentration was a predictor of distant metastasis. The ROC curve determines the optimal threshold of Tg - DT in predicting positive PET/CT is 34.75 months and Tg level at 218.1 ng/ml predicting distant metastasis


Conclusion: Tg - DT is reliable value in predicting positive 18F - FDG PET/CT and serum Tg concentration is valuable for predicting the outcome of distant metastasis in  RAI – R DTC patients.


Keywords: thyroglobulin, thyroglobulin doubling time, differentiated thyroid carcinoma, 18F - FDG PET/CT.

Article Details

Keywords

thyroglobulin, thyroglobulin doubling time, differentiated thyroid carcinoma, 18F - FDG PET/CT.

References

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