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Date Published: 08/07/2022
Online Published: 08/07/2022
Abstract Views: 122
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DOI: https://doi.org/10.55046/vjrnm.01.71.2021
Issue
No. 01 (2021)
Section
Scientific research
How to Cite
Mai Hong , S., Le Quoc , K., Nguyen Thi , P., Nguyen Thi , N., Nguyen Thanh , H., Le Duy, . H., & Le Ngoc , H. (2022). 99mTc-maa spect/ct imaging for treatment response prediction after 90Y-radioembolization in HCC patients: comparison with post-treatment 90Y PET/CT. Vietnamese Journal of Radiology and Nuclear Medicine, 01, 38 - 45. https://doi.org/10.55046/vjrnm.01.71.2021

99mTc-maa spect/ct imaging for treatment response prediction after 90Y-radioembolization in HCC patients: comparison with post-treatment 90Y PET/CT

Mai Hong Son1,, Le Quoc Khanh2, Nguyen Thi Phương2, Nguyen Thi Nhung2, Nguyen Thanh Huong1, Le Duy Hung1, Le Ngoc Ha1
1 108 Hospital
2 108 hospital

Main Article Content

Abstract

90Y PET/CT imaging is performed after radioembolization to re-evaluate the resin microsphere distribution and estimate the absorbed radiation dose of target tumor. However, the distribution of 90Y resin microsphere on PET/CT was different from that of 99mTc-MAA simulation and additive role of PET/CT was not well established until now. The purpose of our
study is to validate the utility of 90Y PET/CT compared to SPECT/CT simulation in dosimetry and prediction of treatment response.
Material and method: Thirty-four consecutive HCC patients, intermediate and advanced stage who underwent 90Y resin microsphere transarterial embolization (TARE) were recruited in the study. Lung shunt fraction (LSF), tumor to-normal liver uptake ratio (TNr) and absorbed dose for target tumors were estimated on 99m Tc-MAA SPECT/CT and 90Y PET/CT. The patients were followed up after treatment within 3 months (2.8 mo ± 0.84) on contrast- enhanced CT to assess treatment response using
mRECIST criteria.
Results: The imaging characteristics of thrombosis uptake was better delineated on PET/CT imaging than SPECT/CT. The agreement and correlation of TNr on PET/CT and SPECT/CT were stronger. Dose delivery to tumor (Dtumor) threshold of 125 Gy estimated on 99mTc-MAA SPECT/CT was more accurate than PET/CT for prediction of treatment response after 90Y- adioembolization in HCC patients with sensitivity of 87.5% and specificity of 90%.
Conclusions: 99mTc-MAA SPECT/CT is superior to PET/CT to predict treatment response after 90Y resin microsphere treatment.

Article Details

References

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