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Role of three tesla magnetic resonance elastography in the assessment of liver fibrosis
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Abstract
Objectives: To investigate liver fibrosis using magnetic resonance elastography (MRE) and the relationship between MRE and histopathology in the assessment of liver fibrosis in patients with chronic viral hepatitis.
Methods: Retrospective study, description, investigation of the liver by MRE before biopsy in 20 patients with chronic viral hepatitis in Cho Ray Hospital from 11/2019 to 05/2021.
Results: The mean age is 51.4 years and 100% of patients are female. The mean liver stiffness (kilopascal = kPa) is 3.1 ± 0.2 (F1, n = 8), 3.6 ± 0.1 (F2, n = 11), 5.3 (F3, n = 1) respectively. The Spearman correlation coefficient is 0.63 (p=0.003), which shows a strong correlation between the liver stiffness measured with MRE and the fibrosis on the liver biopsy sample evaluated by the Metavir scoring system. Based on the ROC curve and the cut-off value of 3.7 kPa, it can be predicted that there is a presence of significant fibrosis (≥ F2), a sensitivity of 58%, and a specificity of 100%.
Conclusions: MRE is a safe and non-invasive technique that can replace biopsy in the assessment of the liver fibrosis stage.
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Keywords
Magnetic resonance elastography, stiffness, liver fibrosis, chronic viral hepatitis, histopathology
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