Relation between T1 and T2 mapping with wall thickness and late gadolinium enhancement of myocardial segments in patients with hypertrophic cardiomyopathy on 3 Tesla magnetic resonance imaging
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Abstract
Object: To investigate T1 and T2 mapping values of local myocardial segments on 3 Tesla Magnetic Resonance Imaging, in patients with hypertrophic cardiomyopathy (HCM). Methods: A prospective- cross-sectional descriptive study recruited 22 patients diagnosed with HCM who underwent 3T Magnetic Resonance at Bach Mai Hospital from 08/2023 to 08/2024.
Results: 73% men, mean age was 51.55 ± 19.69 years. Native T1 values increased in non-hypertrophic, mild, moderate, and severe hypertrophic segments, with the mean values are 1215.17 ± 33.01 ms, 1281.69 ± 15.48ms, 1332.07 ± 11.24 ms and 1378.71 ± 16.74 ms respectively. The mean native T1 values of myocardial segments with LGE were significantly higher than those without LGE, with p < 0.001. The average T2 value increased in the moderate and severe hypertrophy segments with mean values are 49.76 ± 5.30 ms and 48.13 ± 9.80 ms, respectively. Of a total of 352 myocardial segments, 50 segments (14.2%) had late gadolinium enhancement (LGE).
Conclusions: Native T1 and T2 mapping values can provide additional value for HCM diagnosis at an early stage.
Keywords: Hypertrophic cardiomyopathy, T1 and T2 mapping, LGE
Keywords
Hypertrophic cardiomyopathy, T1 and T2 mapping, LGE
Article Details
References
2. Galati G, Leone O, Pasquale F, et al. Histological and Histometric Characterization of Myocardial Fibrosis in End-Stage Hypertrophic Cardiomyopathy. Circ Heart Fail. 2016;9(9):e003090. doi:10.1161/CIRCHEARTFAILURE.116.003090
3. Moon I, Lee SY, Kim HK, et al. Trends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: A nationwide population-based cohort study. PLOS ONE. 2020;15(1):e0227012. doi:10.1371/journal.pone.0227012
4. Zhu F, Li P, Sheng Y. Treatment of myocardial interstitial fibrosis in pathological myocardial hypertrophy. Front Pharmacol. 2022;13:1004181. doi:10.3389/fphar.2022.1004181
5. Bruder O, Wagner A, Jensen CJ, et al. Myocardial Scar Visualized by Cardiovascular Magnetic Resonance Imaging Predicts Major Adverse Events in Patients With Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2010;56(11):875- 887. doi:10.1016/j.jacc.2010.05.007
6. Ho CY, López B, Coelho-Filho OR, et al. Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy. N Engl J Med. 2010;363(6):552-563. doi:10.1056/NEJMoa1002659
7. Ho CY, Abbasi SA, Neilan TG, et al. T1 Measurements Identify Extracellular Volume Expansion in Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers With and Without Left Ventricular Hypertrophy. Circ Cardiovasc Imaging. 2013;6(3):415-422. doi:10.1161/CIRCIMAGING.112.000333
8. Puntmann VO, Voigt T, Chen Z, et al. Native T1 Mapping in Differentiation of Normal Myocardium From Diffuse Disease in Hypertrophic and Dilated Cardiomyopathy. JACC Cardiovasc Imaging. 2013;6(4):475-484. doi:10.1016/j. jcmg.2012.08.019
9. Amano Y, Aita K, Yamada F, Kitamura M, Kumita S. Distribution and Clinical Significance of High Signal Intensity of the Myocardium on T2-Weighted Images in 2 Phenotypes of Hypertrophic Cardiomyopathy. J Comput Assist Tomogr. 2015;39(6):951-955. doi:10.1097/RCT.0000000000000296
10. Xu J, Zhuang B, Sirajuddin A, et al. MRI T1 Mapping in Hypertrophic Cardiomyopathy: Evaluation in Patients Without Late Gadolinium Enhancement and Hemodynamic Obstruction. Radiology. 2020;294(2):275-286. doi:10.1148/radiol.2019190651
11. Huang L, Ran L, Zhao P, et al. MRI native T1 and T2 mapping of myocardial segments in hypertrophic cardiomyopathy: tissue remodeling manifested prior to structure changes. Br J Radiol. 2019;92(1104):20190634. doi:10.1259/bjr.20190634
12. Arcari L, Hinojar R, Engel J, et al. Native T1 and T2 provide distinctive signatures in hypertrophic cardiac conditions – Comparison of uremic, hypertensive and hypertrophic cardiomyopathy. Int J Cardiol. 2020;306:102- 108. doi:10.1016/j.ijcard.2020.03.002
13. Liang X, Garnavi R, Wail S, Sisi Liang null, Prasanna P. Automatic segmentation of the left ventricle into 17 anatomical regions in cardiac MR imaging. Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf. 2015;2015:6531-6535. doi:10.1109/EMBC.2015.7319889
14. Kato S, Nakamori S, Bellm S, et al. Myocardial Native T1 Time in Patients with Hypertrophic Cardiomyopathy. Am J Cardiol. 2016;118(7):1057-1062. doi:10.1016/j.amjcard.2016.07.010
15. Ellims AH, Iles LM, Ling L han, Hare JL, Kaye DM, Taylor AJ. Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2012;14(1):76. doi:10.1186/1532-429X-14-76
16. Dass S, Suttie JJ, Piechnik SK, et al. Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circ Cardiovasc Imaging. 2012;5(6):726-733. doi:10.1161/CIRCIMAGING.112.976738
17. Kim JB, Porreca GJ, Song L, et al. Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science. 2007;316(5830):1481-1484. doi:10.1126/science.1137325