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Date Published:
15/06/2022
Online Published:
15/06/2022
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Views PDF: 840
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Scientific research
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Hoang Minh Loi, Nguyen, T. N. T., & Phung, H. (2022). ASSOCIATION BETWEEN COGNITIVE IMPAIRMENT AND DEMENTIA AND BRAIN DAMAGE ON MAGNETIC RESONANCE IMAGING OF 100 PATIENTS ABOVE 60 YEAR OLD. Vietnamese Journal of Radiology and Nuclear Medicine, 46, 32-45. https://doi.org/10.55046/vjrnm.46.133.2022
ASSOCIATION BETWEEN COGNITIVE IMPAIRMENT AND DEMENTIA AND BRAIN DAMAGE ON MAGNETIC RESONANCE IMAGING OF 100 PATIENTS ABOVE 60 YEAR OLD
Main Article Content
Abstract
Purpose: To study the association between cognitive impairment and dementia and brain damage on magnetic resonance imaging.
Retrospective and Prospective study: A cross-sectional descriptive study with 100 patients above 60 years, made MMSE test brain MRI at Quang Tri Provincial General Hospital since 1/2021-10/2021.
Results: In 100 studied patients, tested by MMSE, 38% had normal cognitive status, 51% had mild cognitive impairment, and 11% had dementia. Cognitive decline is associtated age but not sex. Cognitive impairment and dementia associated with global brain atrophy, medial temporal cephalic atrophy, frontal lobe atrophy, parietal lobe atrophy, and occipital lobe atrophy but not white matter hyperintensities (small vessel disease) and lacunar infarction. The higher the GCA (global corticol atrophy scale), the higher the MTA (mesial tempora atrophy rscale), the more severe the cognitive impairment.
Conclusion: Magnetic resonance imaging is strongly important role for diagonosis cognitive decline and dementia, with features such as total cerebral atrophy, medial temporal brain atrophy, parietal lobe atrophy, frontal lobe atrophy, and occipital lobes atrophy are all involved in the patient's cognitive status, and the assessment of these features on magnetic resonance imaging help to the early diagnosis and prediction of future dementia.
Article Details
References
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Vickers, James C. (2015). Relationship between education and age-related cognitive decline: a review of recent
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21. Mavrodaris, A., Powell, J., & Thorogood, M. (2013). Prevalences of dementia and cognitive impairment among older
people in sub-Saharan Africa: a systematic review. Bulletin of the World Health Organization, 91(10), 773–783.
22. O’brien, J. T. (2007). Role of imaging techniques in the diagnosis of dementia. The British journal of
radiology, 80(special_issue_2), S71-S77.
23. Ojo, Omorogieva; Brooke, Joanne (2015). Evaluating the Association between Diabetes, Cognitive Decline and
Dementia. International Journal of Environmental Research and Public Health, 12(7), 8281–8294.
24. Oudega, Mardien L; Dols, Annemieke; Adelerhof, Ilse; Rozing, Maarten; Wattjes, Mike P.; Comijs, Hannie
C.; Barkhof, Frederik; Eikelenboom, Piet; Stek, Max L.; van Exel, Eric (2015). Contribution of white matter
hyperintensities, medial temporal lobe atrophy and cortical atrophy on outcome, seven to twelve years after ECT
in severely depressed geriatric patients. Journal of Affective Disorders, 185(), 144–148.
25. Pantano, P., Caramia, F., & Pierallini, A. (1999). The role of MRI in dementia. The Italian Journal of Neurological
Sciences, 20(2), S250-S253.
26. Ponjoan, Anna; Garre-Olmo, Josep; Blanch, Jordi; Fages, Ester; Alves-Cabratosa, Lia; Martí-Lluch, Ruth; ComasCufí, Marc; Parramon, Dídac; Garcia-Gil, María; Ramos, Rafel (2019), Epidemiology of dementia: prevalence and
incidence estimates using validated electronic health records from primary care, Clinical Epidemiology, Volume
11(), 217–228.
27. Prins, N. D., & Scheltens, P. (2015). White matter hyperintensities, cognitive impairment and dementia: an
update. Nature Reviews Neurology, 11(3), 157-165.
28. Reisberg, B., Ferris, S. H., Kluger, A., Franssen, E., Wegiel, J., & De Leon, M. J. (2008). Mild cognitive impairment
(MCI): a historical perspective. International Psychogeriatrics, 20(1),
29. Rhodius-Meester, Hanneke F. M.; Benedictus, Marije R.; Wattjes, Mike P.; Barkhof, Frederik; Scheltens,
Philip; Muller, Majon; van der Flier, Wiesje M. (2017). MRI Visual Ratings of Brain Atrophy and White Matter
Hyperintensities across the Spectrum of Cognitive Decline Are Differently Affected by Age and Diagnosis. Frontiers
in Aging Neuroscience, 9(), 117–.
30. Rose, S E (2006). Diffusion indices on magnetic resonance imaging and neuropsychological performance in
amnestic mild cognitive impairment. Journal of Neurology, Neurosurgery & Psychiatry, 77(10), 1122–1128.
31. S tefan J. Teipel; Thomas Meindl; Lea Grinberg; Helmut Heinsen; Harald Hampel (2008). Novel MRI techniques
in the assessment of dementia. , 35(1 Supplement), 58–69.
32. Walker, Keenan A.; Power, Melinda C.; Gottesman, Rebecca F. (2017). Defining the Relationship Between
Hypertension, Cognitive Decline, and Dementia: a Review. Current Hypertension Reports, 19(3), 24–.
33. W. J. Henneman; J. D. Sluimer; C. Cordonnier; M. M. Baak; P. Scheltens; F. Barkhof; W. M. Van Der Flier
(2009). MRI Biomarkers of Vascular Damage and Atrophy Predicting Mortality in a Memory Clinic Population.
2, Lê Đình Dương, Nguyễn Thị Hoài Thương (2017), Suy giảm nhận thức và rối loạn chất lượng giấc ngủ của người
cao tuổi tại thành phố Huế, Tạp chí Y học dự phòng, 27, 15-22.
3. Nguyễn Văn Vy Hậu, Nguyễn Hải Thủy, Hoàng Minh Lợi (2019), Nghiên cứu rối loạn nhận thức qua thang điểm
MMSE và MoCA trên bệnh nhân đái tháo đường type 2 có suy giảm nhận thức, Tạp chí Nội tiết và đái tháo đường,
37, 74-82.
4. Vũ Anh Nhị, Diệp Trọng Khải (2012), Đánh giá suy giảm nhận thức và tổn thương não bằng cộng hưởng từ ở
người lớn tuổi, Tạp chí thần kinh học Việt Nam
5. Huỳnh Thị Thanh Tú, Đoàn Vương Diễm Khánh và các cộng sự (2018), Tỉ lệ suy giảm nhận thức và các yếu tố liên
quan ở người cao tuổi xã Phú An, huyện Phú Vang tỉnh Thừa Thiện Huế năm 2016, Tạp chí Y Dược học-Trường
Đại học Y Dược Huế, 8, 72-75.
6. Al.Janabi, O. M., Panuganti, P., Abner, E. L., Bahrani, A. A., Murphy, R., Bardach, S. H., ... & Jicha, G. A. (2018).
Global cerebral atrophy detected by routine imaging: Relationship with age, hippocampal atrophy, and white
matter hyperintensities. Journal of Neuroimaging, 28(3), 301-306.
7. American Psychiatric Association (2013), “ Diagnostic and Statistical Manual of mental Disorders,. DSM- IV-TR,
4th ed,Washington.
8. Bing Zhang; Ming Li; Zong-Zheng Sun; Bin Zhu; Lei Yuan; Yi Wang; Yun Xu (2009). Evaluation of functional MRI
markers in mild cognitive impairment. , 16(5), 0–641.
9. Binnekade, Tarik T; Perez, Roberto SGM; Maier, Andrea B; Rhodius-Meester, Hanneke FM; Legdeur, Nienke;
Trappenburg, Marijke C; Rhebergen, Didi; Lobbezoo, Frank; Scherder, Erik JA (2019). White matter hyperintensities
are related to pain intensity in an outpatient memory clinic population: preliminary findings. Journal of Pain
Research, Volume 12(), 1621–1629.
10. Bottino, Cssio M. C.; Castro, Cludio C.; Gomes, Regina L. E.; Buchpiguel, Carlos A.; Marchetti, Renato L.; Neto,
Mrio R. Louz (2002). Volumetric MRI Measurements Can Differentiate Alzheimers Disease, Mild Cognitive
Impairment, and Normal Aging. International Psychogeriatrics, 14(1), 59–72.
11. Debette, S., Beiser, A., DeCarli, C., Au, R., Himali, J. J., Kelly-Hayes, M., ... & Seshadri, S. (2010). Association of
MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the
Framingham Offspring Study. Stroke, 41(4), 600-606.
12. E. Duron; O. Hanon (2008). Hypertension, cognitive decline and dementia. , 101(3), 181–189.
13. Elizabeth Guerrero-Berroa; Xiaodong Luo; James Schmeidler; Michael A. Rapp; Karen Dahlman; Hillel T.
Grossman; Vahram Haroutunian; Michal Schnaider Beeri (2009). The MMSE orientation for time domain is a
strong predictor of subsequent cognitive decline in the elderly. , 24(12), 1429–1437.
14. Ercoli, L. M.; Siddarth, P.; Dunkin, J. J.; Bramen, J.; Small, G. W. (2003). MMSE Items Predict Cognitive Decline in
Persons with Genetic Risk for Alzheimer’s Disease. Journal of Geriatric Psychiatry and Neurology, 16(2), 67–73.
15. F.H. Bouwman; S.N.M. Schoonenboom; W.M. van der Flier; E.J. van Elk; A. Kok; F. Barkhof; M.A. Blankenstein;
Ph. Scheltens (2007). CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive
impairment. , 28(7), 0–1074.
16. Jokinen, H.; Lipsanen, J.; Schmidt, R.; Fazekas, F.; Gouw, A. A.; van der Flier, W. M.; Barkhof, F.; Madureira,
S.; Verdelho, A.; Ferro, J. M.; Wallin, A.; Pantoni, L.; Inzitari, D.; Erkinjuntti, T. (2012). Brain atrophy accelerates
cognitive decline in cerebral small vessel disease: The LADIS study. Neurology, 78(22), 1785–1792.
17. Heidi I.L. Jacobs; Martin P.J. Van Boxtel; Harry B.M. Uylings; Ed H.B.M. Gronenschild; Frans R. Verhey; Jelle
Jolles (2011). Atrophy of the parietal lobe in preclinical dementia. , 75(2), 0–163.
18. Gonzales, Mitzi M.; Insel, Philip S.; Nelson, Craig; Tosun, Duygu; Mattsson, Niklas; Mueller, Susanne G.;
Sacuiu, Simona; Bickford, David; Weiner, Michael W.; Mackin, R. Scott (2017). Cortical Atrophy is Associated
with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. The American
Journal of Geriatric Psychiatry, (), S1064748117303032–.
19. Kazazi, Leila; Foroughan, Mahshid; Nejati, Vahid; Shati, Mohsen (2018). Association between age associated
cognitive decline and health related quality of life among Iranian older individuals. Electronic Physician, 10(4),
6663–6671.
20. Lenehan, Megan Elizabeth; Summers, Mathew James; Saunders, Nichole Louise; Summers, Jeffery Joseph;
Vickers, James C. (2015). Relationship between education and age-related cognitive decline: a review of recent
research. Psychogeriatrics, 15(2), 154–162.
21. Mavrodaris, A., Powell, J., & Thorogood, M. (2013). Prevalences of dementia and cognitive impairment among older
people in sub-Saharan Africa: a systematic review. Bulletin of the World Health Organization, 91(10), 773–783.
22. O’brien, J. T. (2007). Role of imaging techniques in the diagnosis of dementia. The British journal of
radiology, 80(special_issue_2), S71-S77.
23. Ojo, Omorogieva; Brooke, Joanne (2015). Evaluating the Association between Diabetes, Cognitive Decline and
Dementia. International Journal of Environmental Research and Public Health, 12(7), 8281–8294.
24. Oudega, Mardien L; Dols, Annemieke; Adelerhof, Ilse; Rozing, Maarten; Wattjes, Mike P.; Comijs, Hannie
C.; Barkhof, Frederik; Eikelenboom, Piet; Stek, Max L.; van Exel, Eric (2015). Contribution of white matter
hyperintensities, medial temporal lobe atrophy and cortical atrophy on outcome, seven to twelve years after ECT
in severely depressed geriatric patients. Journal of Affective Disorders, 185(), 144–148.
25. Pantano, P., Caramia, F., & Pierallini, A. (1999). The role of MRI in dementia. The Italian Journal of Neurological
Sciences, 20(2), S250-S253.
26. Ponjoan, Anna; Garre-Olmo, Josep; Blanch, Jordi; Fages, Ester; Alves-Cabratosa, Lia; Martí-Lluch, Ruth; ComasCufí, Marc; Parramon, Dídac; Garcia-Gil, María; Ramos, Rafel (2019), Epidemiology of dementia: prevalence and
incidence estimates using validated electronic health records from primary care, Clinical Epidemiology, Volume
11(), 217–228.
27. Prins, N. D., & Scheltens, P. (2015). White matter hyperintensities, cognitive impairment and dementia: an
update. Nature Reviews Neurology, 11(3), 157-165.
28. Reisberg, B., Ferris, S. H., Kluger, A., Franssen, E., Wegiel, J., & De Leon, M. J. (2008). Mild cognitive impairment
(MCI): a historical perspective. International Psychogeriatrics, 20(1),
29. Rhodius-Meester, Hanneke F. M.; Benedictus, Marije R.; Wattjes, Mike P.; Barkhof, Frederik; Scheltens,
Philip; Muller, Majon; van der Flier, Wiesje M. (2017). MRI Visual Ratings of Brain Atrophy and White Matter
Hyperintensities across the Spectrum of Cognitive Decline Are Differently Affected by Age and Diagnosis. Frontiers
in Aging Neuroscience, 9(), 117–.
30. Rose, S E (2006). Diffusion indices on magnetic resonance imaging and neuropsychological performance in
amnestic mild cognitive impairment. Journal of Neurology, Neurosurgery & Psychiatry, 77(10), 1122–1128.
31. S tefan J. Teipel; Thomas Meindl; Lea Grinberg; Helmut Heinsen; Harald Hampel (2008). Novel MRI techniques
in the assessment of dementia. , 35(1 Supplement), 58–69.
32. Walker, Keenan A.; Power, Melinda C.; Gottesman, Rebecca F. (2017). Defining the Relationship Between
Hypertension, Cognitive Decline, and Dementia: a Review. Current Hypertension Reports, 19(3), 24–.
33. W. J. Henneman; J. D. Sluimer; C. Cordonnier; M. M. Baak; P. Scheltens; F. Barkhof; W. M. Van Der Flier
(2009). MRI Biomarkers of Vascular Damage and Atrophy Predicting Mortality in a Memory Clinic Population.