The Value of Diffusion Tensor Imaging in Predicting the Histopathological Grade of Diffuse Gliomas in Adults
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Abstract
Objective: The purpose of this study was to determine the value of DTI in preoperative predicting the histological grade of diffuse gliomas in adults.
Subjects and methods: This cross-sectional study included 38 patients with histologically confirmed diffuse gliomas who were treated at the University Medical Center of Ho Chi Minh City between January 2020 and April 2024. Preoperative imaging included conventional MRI and Diffusion Tensor Imaging (DTI). Mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) values were calculated for both the tumor and the peritumor. DTI parameters and tumor grades were statistically analyzed, and receiver operating characteristic (ROC) curve analysis was performed to assess diagnostic performance.
Results: The values of tumor MD, AD, and RD parameters (tMD, tAD, tRD), as well as the peritumoral FA parameter (pFA), showed statistically significant differences between low-grade and high-grade diffuse gliomas.
Conclusion: The values of tMD, tAD, tRD, and pFA parameters demonstrate diagnostic potential in distinguishing between high-grade and low-grade diffuse gliomas.
Keywords
Diffuse Gliomas, Diffusion Tensor Imaging, Fractional Anisotropy, Mean Diffusivity, Axial Diffusivity, Radial Diffusivity
Article Details
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