Nghiên cứu giá trị của cộng hưởng từ tưới máu trong chẩn đoán và phân loại mô bệnh học của ung thư vú

Abstract

Objective: To investigate wherethe the perfusion parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) had correlation with molecular subtypes of breast invase ductal carcinoma (IDC).

Methods: Forty patients underwent 3T MRI examination following biopsied pathological immunohistochemistry at Bach Mai Hospital from March 2021 to July 2022 were retrospectively investigated. The volume transfer constant (Ktrans), the rate constant (Kep) and the plasma volume ratio (Ve) were calculated from DCE-MRI base on the extended Tofts model. The mean and standard deviation of each perfusion parameters and the pathological immunohistochemistry, subtypes correlations were assessed by Mann-Whitney U test and One-way ANOVA.

Results: 40 IDC patients (mean age, 55,5 ± 11.6; range, 38 to 82 years) were investigated. The mean of Kep was higher in tumors with estrogen receptor (ER) negative (p = 0.03), progesterone receptor (PR) negative (p = 0.03), human epidermal growth factor receptor 2 (HER-2) positive (p = 0.02) than that in tumors with ER-positive, PR-positive, and HER-2-negative. Also, Kep was significantly higher in HER-2 enriched tumors than that in luminal B tumors (p = 0.01) and triple-negative tumors (p < 0.05).

Conclusion:   DCE-MRI may be used as the non-invase tool to assess the molecular biological expression and the molecular subtypes of invase ductal breast cancer.