Study of imaging characteristic and value of MRI in diagnosis of hemisphere glioblastoma

Mai The Canh1, Nguyen Duy Hue2,
1 University Hospital Medical Hanoi
2 Hanoi Medical University

Main Article Content

Abstract

SUMMARY


Purpose: Describing imaging characteristic and assessing the MRI value in the diagnosis of hemisphere glioblastoma.
Materials and methods: 2505 patients of brain tumors were selected in retrospective describe study, diagnosed, operated and having histopathological result from January 2009 to March 2011 in Viet Duc Hospital, in which 45 patients were histologically confirmed
of glioblastoma. Based on gold standard of histopathology, the value of MRI in diagnosis of hemisphere glioblastoma was assessed.
Results: Mean age 51±16. Gender: M/F 1.3/1. Location at frontal lobe (26.4%), fronto -temporal lobe (20%), less frequently at occipital lobe. Average diameter more than 5cm (60.4%). Hyposignal on T1W (66%), hypersignal on T2W (70%), marked and heterogenous enhancement (43.4%), rim enhancement (47.3), necrosis (95.6%), cyst component (52.8%), hemorrhage (28.4%); surrounding edema of grade II and III (90%), meningeal and copus callosum invasion (47.2% and 39.6%, respectively). Accurate diagnosis of tumor location was 100% comparing to surgery. Se, Sp and Acc respectively 81.1%, 97.6%, and 98%.
Conclusion: MRI had high value in diagnosis of hemisphere glioblastoma.

Article Details

References

TÀI LIỆU THAM KHẢO
1. Nguyễn Quốc Dũng (1995), “Nghiên cứu chẩn 1. đoán và phân loại các khối u trong hộp sọ bằng CLVT”, Luận án Phó Tiến sĩ Y dược.
2. ABM Salah Uddin, Stephen A Berman, MD, 2. PhD (2010), “Neurologic Manifestations of Glioblastoma Multiforme Clinical Presentation”, emedicine.
3. Alex Lobera (2009), “Imaging in Glioblastoma 3. Multifome”, Radiology.
4. Batzdorf U, Malamud N (1963), “The problem 4. of multicentric gliomas”, J Neurosurg, 20, tr.122-136.
5. Daumas-Duport C, Scheithauer B, O’Fallon J, 5. Kelly P (1988), “Grading of astrocytomas”, Cancer, 62, tr.2152-65.
6. David A Altman, MD. Denis S. Atkinson Jr, MD. 6. Daniel J. Brat, MD, PhD (2007), “Best Cases from the AFIP Glioblastoma Multiforme”, RadioGraphics, 27, tr.883-888.
7. Jeffrey N Bruce (2009), “Glioblastoma 7. Multiforme”, emedicine.medcape.com, (oncology).
8. Joyce Moore-Stovall, MD, and Ram Venkatesh, 8. MD and Kansas Leavenworth (1993), “Serial nonenhancing magnetic resonance”.
9. Kimberley Mark, Gillian Lieberman MD (2008),“Imaging Gliblastoma Multiforme: Diagnosis, Treatment, and Follow-Up “, Radiographics, 3(1), tr.722-34.
10. Marc R.J. Carlson, Whitney B. Pope, Steve 10. Horvath, Jerome G. Braunstein, Phioanh Nghiemphu, Cho-Lea Tso, Ingo Mellinghoff,, et al (2007), “Relationship between Survival and Edema in Malignant Gliomas: Role of Vascular Endothelial Growth Factor and Neuronal Pentraxin 2”, Clin Cancer Res, 13, tr.2592.
11. Osborn. G Anne MD, Karen L Salzman MD, 11. A. James Barkovich (2000), “Diagnostic imaging Brain: Glioblastoma Multiforme”, Amirsys® Hardbound.
12. RongY, Durden DL, Van Meir EG, Brat DJ 12. (2006), “Pseudopalisading necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis”, J Neuropathol Exp Neurol, 65(6), tr.529-539.
13. Shuangshoti S, Kasantikul V, Suwanwela N (1987), 13. “Spontaneous penetration of dura mater and bone by glioblastoma multiforme”, JJ Surg Oncol, 36(1), tr.36-44.