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Date Published: 11/07/2022
Online Published: 11/07/2022
Abstract Views: 102
Views PDF: 481
DOI: https://doi.org/10.55046/vjrnm.8.226.2012
Issue
No. 8 (2012)
Section
Scientific research
How to Cite
Ngo, T. K. L., Huynh, T. T. T., Ha, T. N., Nguyen, T. D., Nguyen, D. P., Le , T. K., & Tran, C. T. (2022). Chromosomal defects’ evaluation with new ultrasound markers in first trimester having high genetic risk pregnancies. Vietnamese Journal of Radiology and Nuclear Medicine, 8, 240-246. https://doi.org/10.55046/vjrnm.8.226.2012

Chromosomal defects’ evaluation with new ultrasound markers in first trimester having high genetic risk pregnancies

Dr Ngo Thi Kim Loan1, Dr Huynh Thi Thu Thuy1, Dr Ha To Nguyen1, Dr Nguyen Te Dang1, Dr Nguyen Duy Phong2, Dr Le Trong Khoan3, Dr Tran Cong Toai4
1 Tu Du Hospital
2 Department of Infections University Medicine and Pharmacy in Ho Chi Minh City
3 College of Education Department Cardinal Hue
4 Department of Embryonic Tissue School University of Medicine and Pharmacy and University of Medicine Pham Ngoc Thach TP Ho Chi Minh

Main Article Content

Abstract

Objective: To determine sensitivity (Se), specificity (Sp), false positive rate (FPR), positive predictive value (PPV) of new ultrasound markers on high genetic risk pregnancies between weeks 11 and 14. Before CVS procedure, the new ultrasound markers nasal bone(NB), DV and TR were assessed. We determined diagnostic evaluation of new ultrasound markers based on ultrasound findings and genetic results from CVS – gold standard.
Results: NB marker: Se: 60%, Sp: 97.1%, FPR: 2.9% for T21. Se: 60%, Sp: 94.5%, FPR: 5.5% for T18. Se: 50%, Sp: 93.6%, FPR: 6,4% for T13. Se: 100%, Sp: 92.9%, FPR::7,1% forTurner syndrome. DV marker: Se: 70%, Sp: 96.2,1%, FPR: 3.8% for T21. Sens: 60%, Spec: 92.7%, FPR: 7.3% for T18. Se: 50%, Sp: 91.8%, FPR: 8.2% forT13. Se: 100%, Sp: 91.1%, FPR: 8.9% forTurner syndrome. TR marker: Sens: 60%, Sp 96.1%, FPR: 3.9% for T21. Se: 40%, Sp: 92.7%, FPR: 73%, for T18. Se: 50%, Sp: 92.7%, FPR: 7.3% for T13. Se: 100%, Sp: 92%, FPR: 8.0% for Turner syndrome. Combine 3 new markers for detecting chromosome defects: Increase Se, Sp and decrease FPR.Se: 60%, Sp: 97,1%, FPR: 2,9%. Reducing 73% placental biopsies…
Conclusion: New ultrasound markers in the first trimester improved diagnostic evaluation of chromosome defects and
avoiding unnecessary placental biopsy.

Article Details

Keywords

Chorionic villus sampling, nasal bone, ductus venosus, tricuspid flow.

References

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