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Date Published: 11/07/2022
Online Published: 11/07/2022
Abstract Views: 177
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DOI: https://doi.org/10.55046/vjrnm.8.252.2012
Issue
No. 8 (2012)
Section
Scientific research
How to Cite
Bui, Q. B., & Le , N. H. (2022). Value of PET /CT and diagnostic CT scan in differentiated thyroid carcinoma patients with high serum thyroglobulin and negative 131I whole body scan. Vietnamese Journal of Radiology and Nuclear Medicine, 8, 261-268. https://doi.org/10.55046/vjrnm.8.252.2012

Value of PET /CT and diagnostic CT scan in differentiated thyroid carcinoma patients with high serum thyroglobulin and negative 131I whole body scan

Dr Bui Quang Bieu1, Dr Le Ngoc Ha1
1 Faculty of Nuclear Medicine, Diseases Military Central Institute 108

Main Article Content

Abstract

Objective: to determine value of FDG-PET/CT and diagnostic CT scan in post-surgical differentiated thyroid carcinoma patients
with high serum thyroglobulin and negative 131I whole body scan.


Patients and method: We performed FDG-PET/CT and diagnostic CT scan in 49 post-surgical differentiated thyroid carcinoma patients with high serum thyroglobulin and negative 131I whole body scan who already underwent 131I therapy in Department
of Nuclear Medicine, 108 Central Military Hospital.
Results: 41 lesions detected in 29/49 patients (59.2%) with positive PET/CT scan compared to only 20 lesions 18/49 patients
(36.7%) detected on positive CT scan. The Sn, Ac and NPV of FDG-PET/CT were 83.9%, 83.7% and 75% higher than those of CT
(51.6%, 65.3% and 51.6%, respectively). Sp and PPV of FDG-PET/ CT (83.3% and 89.7%, respectively) were similar to those of CT
(88.9%). SUVmax thresholds with good diagnostic value were 4.5 (Sn 84.6%, Sp 66.7%) and 5.0 ( Sn 65.3%, Sp 100%). FDG-PET/CT
had altered treatment plan in 25/49 patients (51.2%).
Conclusion: FDG-PET/CT is superior than CT in detecting reccurent/metastatic lesions in post-surgical differentiated thyroid
carcinoma patients with high serum thyroglobulin and negative 131I whole body scan.

Article Details

Keywords

FDG PET/CT, CT, differentiated thyroid carcinoma

References

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