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Initial evaluation of the role of FDG -PET /CT in diagnosis and radiotherapy planification of nasopharyngeal carcinoma (NPC)
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Abstract
SUMMARY
NPC (cavum) is a common disease in the world (1% world population according to UICC) and one of leading causes of death in South China as well as in most of ASEAN countries. PET/ CT (Positron Emission Tomography/Computed Tomography) is a modern imaging modality, playing an important role in management of NPC. Applications of FDG-PET/CT in NPC are diagnosis, staging, restaging for recurrence, monitoring therapeutic response and radiotherapy planning.
Purposes: Initial evaluation of role of PET/CT in diagnosis
and radiotherapy planning for 20 NPC patients (cavum tumor).
Objects and research method: 20 patients with determined
diagnosis of NPC with anapathological results, received PET/CT
in Nuclear medicine and Oncology Center, Bach Mai hospital for
diagnosing, staging and emulating radiotherapy plan from July
2010 to January 2011.
Results: 1. FDG-PET/CT is very valuable in diagnosing and staging NPC including detection of primary tumor in metastasic patients with unknown origin; Importance of FDG uptake (SUV value) is high at cavum (mean SUV = 11.83), at metastatic ganglions (mean SUV= 8.37) helping detection, staging modified in 38.9% patients, modifying treatment way as well as better prognosing. 2. FDG-PET/CT is usefull in planning NPC radiotherapy by helping exactly BTV, without omission of regional ganglions, modifying volume of radiotherapy in 80% patients in compared with conventional emulation by CT, reducing volume of radiotherapy in 60% patients, limiting complications due to radiation. Mean GVT-PET volume is about 92.3 cm3 in compared with GTV-CT (128.4 cm3).
Conclusion: Using FDG-PET/CT is a highly effective and safe technics in diagnosing and emulating radiotherapy plans for NPC patients.
Article Details
Keywords
PET/CT, diagnosing, emulating, radiotherapy, NPC
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