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Application of 18FDG PET/CT in patients of pulmonary tuberculosis
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Abstract
The study was performed on a PET/CT system provided by Philips Health Care System, radioactive drug 18FDG of the 108 Military Hospital. The procedure was based on recommendations of EANM (European Association of Nuclear Medicine) and protocol. PET/CT scan of the Ministry of Health. The technique was performed on 15 patients with a confirmed diagnosis of pulmonary TB by microbiological results being treated with anti-tuberculosis drugs.
Results: There are two patterns of 18FDG uptake in TB patients: the lung parenchyma and the lymphatic system. Before treatment: Metabolic change in the mean SUVmax index found in lung parenchymal lesions was 6.75±3.01. Mediastinal lymph nodes were found in 10/15 patients (66.7%), in which 8/10 lymph nodes increased FDG uptake with mean SUVmax of 3.14±1.5.
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Keywords
pulmonary tuberculosis, 18FDG PET/CT
References
2. TB profile. https://worldhealthorg.shinyapps.io/tb_profiles
3. Jamar F., Buscombe J., Chiti A. và cộng sự. (2013). EANM/SNMMI guideline for 18F-FDG use in inflammation and infection.
4. Hướng dẫn chẩn đoán và điều trị YHHN. Bộ y tế.
5. Zhuang H. và Alavi A. (2002). 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med, 32(1), 47–59.
6. Kubota R., Yamada S., Kubota K. và cộng sự. (1992). Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography.
7. White A.G., Maiello P., Coleman M.T. và cộng sự. (2017). Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates. J Vis Exp JoVE, (127), 56375.
8. Soussan M., Brillet P.-Y., Mekinian A. và cộng sự. (2012). Patterns of pulmonary tuberculosis on FDG-PET/CT. Eur J Radiol, 81(10), 2872–2876.
9. Sathekge M.M., Maes A., Pottel H. và cộng sự. (2010). Dual time-point FDG PET-CT for differentiating benign from malignant solitary pulmonary nodules in a TB endemic area. South Afr Med J Suid-Afr Tydskr Vir Geneeskd.
10. World Health Organization (2017), Guidelines for treatment of drug-susceptible tuberculosis and patient care: 2017 update.
11. Coleman M.T., Chen R.Y., Lee M. và cộng sự. (2014). PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis. Sci Transl Med, 6(265).
12. Lawal I.O., Fourie B.P., Mathebula M. và cộng sự. (2020). 18F-FDG PET/CT as a Noninvasive Biomarker for Assessing Adequacy of Treatment and Predicting Relapse in Patients Treated for Pulmonary Tuberculosis. J Nucl Med Off Publ Soc Nucl Med, 61 (3).