Article Sidebar
Views PDF: 227
ĐỘ DÀI XƯƠNG MŨI THAI NHI Ở TUỔI THAI TỪ 19-26 TUẦN TẠI VIỆT NAM
Main Article Content
Abstract
Aim: The purpose of this study was to establish the normal range of fetal nasal bone length (NBL) at the second trimester of gestation in Vietnamese pregnancies.
Methods: A prospective cross-sectional study was carried out. A total of 2432 singleton pregnancies were evaluated for fetal NBL at 19–26 weeks 6 days between 1 January 2013 and 31 December 2014. Three measurements of NBL were taken and the largest value was chosen. Fetal anomalies and neonatal abnormalities were excluded.
Results: Mean fetal NBL was 6.75 ± 0.82 mm and mean gestational age was 22.2 ± 1.4 weeks. Median NBL increased
linearly with advancing gestational age: NBL (mm) = 0.26 × gestational age (weeks) + 1.03 (R2 = 0.20; P <0.000). The fifth percentile of fetal NBL ranged from 4.6 to 6.3 mm, corresponding with gestational age 19–26 weeks.
Conclusion: The normal range ofNBLwas established at second trimester inVietnamese pregnancies. NBL at the fifth percentile for gestational age was different from that of other Asian ethnicities. It is necessary to define short NBL or hypoplasia of NBL with regard to ethnicity.
Article Details
Keywords
Down syndrome, fetal nasal bone length, ultrasonography.
References
2. Masihi S, Barati M, Mohamadjafari R, Hashemi M. Assessment of nasal bone in first trimester screening for chromosomal abnormalities in Khuzestan. Iran J Reprod Med 2014;12:321–326.
3. Sonek JD. Nasal bone evaluation with ultrasonography: A marker for fetal aneuploidy. Ultrasound Obstet Gynecol 2003; 22:11–15.
4. Bunduki V, Ruano R, Miguelez J, Yoshizaki CT, Kahhale S,Zugaib M. Fetal nasal bone length: Reference range and clinical application in ultrasound screening for trisomy 21. Ultrasound Obstet Gynecol 2003; 21:156–160.
5. Narayani BH, Radhakrishnan P. Mid-second trimester measurement of nasal bone length in the Indian population. J Obstet Gynaecol India 2013; 63 :256–259.
6. Papasozomenou P, Athanasiadis AP, Zafrakas M et al.Fetal nasal bone length in the second trimester: Comparison between population groups from different ethnic origins.JPerinatMed 2016;44:229–235.
7. Zelop CM, Milewski E, Brault K, Benn P, Borgida AF, Egan JF.Variation of fetal nasal bone length in second-trimester fetuses according to race and ethnicity. J Ultrasound Med 2005; 24:1487–1489.
8. Kanagawa T, Fukuda H, Kinugasa Y et al. Midsecond trimester measurement of fetal nasal bone length in the Japanese population. J Obstet Gynaecol Res 2006; 32:403–407.
9. Sutthibenjakul S, Suntharasaj T, Suwanrath C, Kor-anantakul O, Geater A. A Thai reference for normal fetal nasal bone length at 15 to 23 weeks’ gestation. J Ultrasound Med 2009;28:49–53.
10. Vietbao.vn. [Screening Down syndrome in pregnancy.] 2005[Cited 28 July 2005] Available from URL: http://vietbao.vn/ Suc-khoe/Tam-soat-hoi-chung- Down-trong-thai-ky/ 10919504/248/ (in Vietnamese).
11. Cicero S, Sonek JD, McKenna DS, Croom CS, Johnson L,Nicolaides KH. Nasal bone hypoplasia in trisomy 21 at 15-22 weeks’ gestation. Ultrasound Obstet Gynecol 2003; 21:15–18.
12. Dukhovny S, Wilkins-Haug L, Shipp TD, Benson CB, Kaimal AJ, Reiss R. Absent fetal nasal bone: What does it mean for the euploid fetus? J Ultrasound Med 2013; 32: 2131–2134.
13. Sandikcioglu M, Molsted K, Kjaer I. The prenatal development of the human nasal and vomeral bones.J Craniofac Genet Dev Biol 1994;14:124–134.
14. Goncalves LF, Espinoza J, Lee Wet al.Phenotypic characteristics of absent and hypoplastic nasal bones in fetuses with Down syndrome: Description by 3-dimensional ultrasonography and clinical significance.JUltrasoundMed 2004;23:1619–1627.
15. Cusick W, Provenzano J, Sullivan CA, Gallousis FM, Rodis JF.Fetal nasal bone length in euploid and aneuploid fetuses between 11 and 20 weeks’gestation: A prospective study.J Ultrasound Med 2004;23:1327–1333.
16. Prefumo F, Sairam S, Bhide A, Penna L, Hollis B, ThilaganathanB. Maternal ethnic origin and fetal nasal bones at 11-14 weeks of gestation.BJOG
2004;111:109–112.
17. Cusick W, Shevell T, Duchan LS, Lupinacci CA, Terranova J,Crombleholme WR. Likelihood ratios for fetal trisomy 21 based on nasal bone length in the second trimester: How best to define hypoplasia? Ultrasound Obstet Gynecol 2007;30:271–274.
18. Odibo AO, Sehdev HM, Dunn L, McDonald R, Macones GA.The association between fetal nasal bone hypoplasia and aneuploidy. Obstet Gynecol 2004;104:1229–1233.
19. Chen M, Lee CP, Leung KY, Hui PW, Tang MH. Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population.Prenat Diagn 2004;24:87–91.
20. Odibo AO, Sehdev HM, Stamilio DM, Cahill A, Dunn L,Macones GA. Defining nasal bone hypoplasia in second-trimester Down syndrome screening: Does the use of multiplesof the median improve screening efficacy? Am J Obstet Gynecol 2007;197:361e1–361 e4.
21. www.rightdiagnosis.com Statistic by country for Down syndrome: Incidence (annual for Down syndrome). [Cited 2004] Available from URL: http:// www.rightdiagnosis.com/d/down_syndrome/statscountry. htm#extrapwarning
22. Sharma A, Tayal T, Narayani BH, Radhakrishnan P, Kaul A.Nasal bone length: The long and short of it. Evaluation of the reference values for the fetal nasal bone length at 16 to 25 weeksof gestational age in an Indian population.Prenat Diagn 2013;33:800–803. Fetal nasal bone length at 19–26 weeks’ gestation in Vietnam Xuan-Hong Tomai1 and Thanh-Hai Phan2 1Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy, and 2Medic Medical Center, Ho Chi Minh City,