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The clinical characteristics of rai refractory differentiated thyriod cancer
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Abstract
SUMMARY
Objectives: to determine clinical characteristics of RAI refractory differentiated thyroid carcinoma patients.
Material and methods: 30 post-surgical and treated with I-131 differentiated thyroid carcinoma patients, diagnosed RAI refractory were enrolled in the study in 108 Military Centre Hospital from January 2017 to Jun 2017.
Results: RAI refractory differentiated thyroid carcinoma has more frequently seen in middle aged, female patients (female to male ratio 3.2/1). Papillary and folicullar carcinoma represents 86.7% and 6.7% respectively. 40% of patients were in stage I and 53.4% in stage VI (AJCC7). The distant metastases were detected in 13.3% of patients. The median of time from initial diagnosis to RAI refractory were 21.5 months. I-131 treatment courses were 2.47 ± 1.13. The mean total dose was 301,8 mCi. 70% of the patients were in group I; 10% in group II and the rate of group III and IV were 6.7 and 13.3% respectively according to the ATA RAI refractory classification of DTC. 80% of patients had one RAI refractory lesion; 76.8% had metastasis in the neck lymph nodes and 16.7% had recurrent malignant lesions in the thyroid bed.
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Keywords
differentiated thyroid carcinoma, RAI refractory differentiated thyroid carcinoma
References
1. Phạm Thị Minh Bảo, Lê Ngọc Hà và cộng sự (2007). Nghiên cứu một số một số đặc điểm lâm sàng và kết quả điều trị ung thư tuyến giáp biệt hóa sau phẫu thuật bằng I-131 tại bệnh viện Trung ương quân đội 108. Đề tài nghiên cứu khoa học cấp Bộ Quốc phòng.
2. Nguyễn Thị Lan Hương và cộng sự (2013). Đánh giá kết quả điều trị ung thư giáp trạng thể biệt hoá sau phẫu thuật bằng I-131 tại Viện Y học phóng xạ và U bướu quân đội. Y học lâm sàng 108, tập 8, tr.162-167.
3. Francis Worden (2014). Treatment stratergies for radioactive iodine- refractory differentiated thyroid cancer. Ther Adv Med Oncol 6161: 267-279.
4. Brian R. Haugen, Erik K. Alexander, Keith C. Bible (2016). 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26 (1):1-133.
5. NCCN Clinical Practice Guidelines in Oncology: Thyroid Carcinoma. V.1. 2016.
6. Fernanda Vaisman, Denise P, Mario Vaisman (2014). A new appraisal of iodine refractory thyroid cancer. European Journal of Endocrinology 22:301-310.