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Date Published: 08/07/2022
Online Published: 08/07/2022
Abstract Views: 141
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DOI: https://doi.org/10.55046/vjrnm.30.517.2018
Issue
No. 30 (2018)
Section
Scientific research
How to Cite
Mai, H. S., Nguyen, T. N., Nguyen, T. H., Le, N. H., Thai, D. K., Dinh, T. G., Nguyen, T. T., & Dao, D. T. (2022). Characteristics of Post- Selective Internal Radiation Therapy (SIRT)90 Y Microsphere PET/CT in Hepatocellular Carcinoma Comparison With 99mTc Macroaggregated Albumin (MAA) scan. Vietnamese Journal of Radiology and Nuclear Medicine, 30, 62-69. https://doi.org/10.55046/vjrnm.30.517.2018

Characteristics of Post- Selective Internal Radiation Therapy (SIRT)90 Y Microsphere PET/CT in Hepatocellular Carcinoma Comparison With 99mTc Macroaggregated Albumin (MAA) scan

Mai Hồng Sơn1, Nguyen Thị Nhung1, Nguyen Thanh Huong1, Le Ngoc Ha1, Thai Doan Ky2, Dinh Truong Giang2, Nguyen Tien Thinh2, Dao Duc Tien3,
1 Department of Nuclear Medicine, Central Military Hospital 108
2 Department of Internal Gastroenterology, 108 Central Hospital
3 Department of Gastroenterology, Military Hospital 175

Main Article Content

Abstract

SUMMARY


Purpose: 90Y microspheres are recommended for intra-arterial treatment of hepatocellular carcinoma. Before treatment,99mTc-labelled
macroaggregated albumin (MAA) is injected intra-arterially to simulate the treatment and
yttirum-90 (90Y PET/CT) images is performed to evaluate posttreatment. The aim of the study is to assess the correlation between the pretreatment planning and posttreatment images.
Methods: Twenty patients with the intermediate and advanced stage of HCC were reviewed in this study. 99mTc-MAA was injected intra -arterially before treatment and whole body scintigraphy
and abdominal SPECT was done after 60 min.Post-injection of 90Y microspheres (SIRTEX, Australia), the patients underwent posttreatment 90Y PET/CTwithin 24 h. The tumor to normal ratios (T/N ratios) on PET/CT and SPECT were analyzed and correlated using Spearman rank correlation test.
Results: In 20 patients, the distribution of microspheres was consistently demonstrated in both 99mTc-MAA planar scintigraphy before therapy and posttreatmentPET/CT images. Agood correlation was observed between T/N on scintigraphy before treatment and T/N on PET/CT images after treatment (rho value=0.58, p<0.005). The TN on PET/CT (median 14.85) tends to show significantly higher values than T/N stimulated (median 11.2, p<0.05). The T/N post treatment showed good correlation with tumor volume (rho=0.69, p<0.05).
Conclusions: The 99m-Tc MAA planar imgaes showed a good
correlation with 90Y PET/CT in T/N values, suggesting that it should
be used as an adequate pretreatment evaluation method. 90Y PET/CT
should be included routinely in
the post-therapeutic evaluation.

Article Details

Keywords

resin microspheres 90Y, 99mTc-MAA, hepatocellular carcinoma

References

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