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Date Published: 08/07/2022
Online Published: 08/07/2022
Abstract Views: 164
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DOI: https://doi.org/10.55046/vjrnm.31.521.2018
Issue
No. 31 (2018)
Section
Scientific research
How to Cite
Than, V. S., Nguyen, D. H., & Pham, C. H. (2022). Perfusion mri in differentiation of glioblastoma multiforme from solitary brain metastasis. Vietnamese Journal of Radiology and Nuclear Medicine, 31, 17-22. https://doi.org/10.55046/vjrnm.31.521.2018

Perfusion mri in differentiation of glioblastoma multiforme from solitary brain metastasis

Dr Than Van Sy1, Dr Nguyen Duy Hung2, Dr Pham Chu Hoang3
1 Faculty of College of Medicine of the Hospital Vietnamese Germany.
2 Department of College of Education Ha Noi medical university
3 Faculty of College of Medicine of the Hospital Ha Noi medical university.

Main Article Content

Abstract

Objective: Objective of this study is to describe the value of Perfusion MR Imaging in the differentiation of glioblastoma from solitary brain metastasis.
Material and Methods: Between 06/2015 and 04/2017, a descriptive cross-sectional study involved 58 patients with solitary brain tumor (26 solitary brain metastases and 32 glioblastomas) underwent preoperative conventional MR Imaging, Perfusion MR Imaging and histopathologically determined glioblastomas or metastases after stereotactic biopsy or partial resection. The conventional MR Imaging and Perfusion MR Imaging in these patients were analysed. Relative cerebral blood volume (rCBV)
was calculated and receiver operating characteristic (ROC) analysis was performed. To obtain the cut-off value of rCBV presenting a statistical difference between the two tumors groups.
Results:Tumoral rCBV ratio presented no significant different between two tumor groups. Peritumoral rCBV ratios of glioblastomas (1,44 ± 0,52) significantly differentiated from those of solitary brain metastases (0,63 ± 0,31) (p = 0,935). The cut-off value was taken as 1,045 in the peritumoral rCBV ratio provided sensitivity, specificity, PPV and NPV of 90,6 %, 92,6%, 96,67% and 89,92%, respectively.
Conclusion:Perfusion-weighted MR imaging enable distinction between glioblastoma and solitary brain metastasis

Article Details

Keywords

Glioblastoma, Solitary brain metastasis, Perfusion MR Imaging.

References

1. E. S. Nussbaum, H. R. Djalilian, K. H. Cho và cộng sự (1996). Brain metastases: histology, multiplicity, surgery, and survival. Cancer, 78 (8), 1781-1788.
2. I. Tsougos, P. Svolos, E. Kousi và cộng sự (2012). Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. Cancer Imaging, 12 (3), 423.
3. K. H. Cho, W. A. Hall, A. K. Lee và cộng sự (1998). Stereotactic radiosurgery for patients with single brain metastasis. Journal of Radiosurgery, 1 (2), 79-85.
4. R. M. Auchter, J. P. Lamond, E. Alexander và cộng sự (1996). A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis. International Journal of Radiation Oncology* Biology* Physics, 35 (1), 27-35.
5. C. E. Fadul, P. Y. Wen, L. Kim và cộng sự (2008). Cytotoxic chemotherapeutic management of newly diagnosed glioblastoma multiforme. Journal of neuro-oncology,89 (3), 339-357.
6. A. H. Bauer, W. Erly, F. G. Moser và cộng sự (2015). Differentiation of solitary brain metastasis from glioblastoma multiforme: a predictive multiparametric approach using combined MR diffusion and perfusion. Neuroradiology, 57 (7), 697-703.
7. P. Lemercier, S. P. Maya, J. T. Patrie và cộng sự (2014). Gradient of apparent diffusion coefficient values in peritumoral edema helps in differentiation of glioblastoma from solitary metastatic lesions. American Journal of Roentgenology, 203 (1), 163-169.
8. M. Essig, T. B. Nguyen, M. S. Shiroishi và cộng sự (2013). Perfusion MRI: the five most frequently asked clinical questions. American Journal of Roentgenology, 201 (3), W495-W510.
9. N. O. Halshtok, S. Sadetzki, A. Chetrit và cộng sự (2013). Perfusion-weighted imaging of peritumoral edema can aid in the differential diagnosis of glioblastoma mulltiforme versus brain metastasis. The Israel Medical Association journal: IMAJ, 15 (2), 103-105.
10. B. Hakyemez, C. Erdogan, G. Gokalp và cộng sự (2010). Solitary metastases and high-grade gliomas: radiological differentiation by morphometric analysis and perfusion-weighted MRI. Clinical radiology,65 (1), 15-20.
11. S. Blasel, A. Jurcoane, K. Franz và cộng sự (2010). Elevated peritumoural rCBV values as a mean to differentiate metastases from high-grade gliomas. Acta neurochirurgica, 152 (11), 1893-1899.
12. I. C. Chiang, Y.-T. Kuo, C.-Y. Lu và cộng sự (2004). Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings. Neuroradiology, 46 (8), 619-627.
13. S. Cha, J. Lupo, M.-H. Chen và cộng sự (2007). Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibilityweighted contrast-enhanced perfusion MR imaging. American Journal of Neuroradiology, 28 (6), 1078-1084.
14. M. Law, S. Cha, E. A. Knopp và cộng sự (2002). High-Grade Gliomas and Solitary Metastases: Differentiation by Using Perfusion and Proton Spectroscopic MR Imaging 1. Radiology, 222 (3), 715-721.