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A study on the role of arterial spin labeling technique (ASL) in the grading of astrocytoma
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Abstract
SUMMARY
Objective: Assessing the role of perfusion in grading astrocytoma with arterial spin labeling. Studying the value and correlation between
relative cerebral blood flow (rCBF) and with the grade of astrocytoma.
Method: A descriptive study was carried out at Cho Ray Hospital from March 2017 to June 2018. All MR imaging examinations were performed on a 3 Tesla MR imaging system Skyra (Siemens, Germany). Pulsed ASL technique was acquired for all the patients. For each patient, relative CBF values of the lesions were obtained by dividing
the CBF values of tumors to the normal appearing symmetric region on the contralateral hemisphere. The value and correlation between rCBF and the grade of astrocytoma were studied.
Result: 19 cases with histopathologically proven gliomas were studied (7 male, 12 female; age range = 21 to 66 years, mean age =
44,16 years). Hide-grade astrocytomas were 78,95% and low-grades were 21,05%. With a cut-off value of 3,095, rCBF predicts high grade
astrocytoma with sensitivity of 93,33%, specificity of 100%, PPV of 100%, NPV of 100%, accuracy of 94,74%. rCBF correlated positively with the grade of astrocytoma (r = 0,613, p < 0,01).
Conclusion: The rCBF plays an important role in predicting low and high grade astrocytoma. rCBF correlated positively with grade astrocytoma.
Article Details
Keywords
Astrocytoma, relative cerebral blood flow (rCBF), correlation, low and high grade of astrocytoma
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