Article Sidebar
Views PDF: 68
A study on the role of arterial spin labeling technique (ASL) in the grading of astrocytoma
Main Article Content
Abstract
SUMMARY
Objective: Assessing the role of perfusion in grading astrocytoma with arterial spin labeling. Studying the value and correlation between
relative cerebral blood flow (rCBF) and with the grade of astrocytoma.
Method: A descriptive study was carried out at Cho Ray Hospital from March 2017 to June 2018. All MR imaging examinations were performed on a 3 Tesla MR imaging system Skyra (Siemens, Germany). Pulsed ASL technique was acquired for all the patients. For each patient, relative CBF values of the lesions were obtained by dividing
the CBF values of tumors to the normal appearing symmetric region on the contralateral hemisphere. The value and correlation between rCBF and the grade of astrocytoma were studied.
Result: 19 cases with histopathologically proven gliomas were studied (7 male, 12 female; age range = 21 to 66 years, mean age =
44,16 years). Hide-grade astrocytomas were 78,95% and low-grades were 21,05%. With a cut-off value of 3,095, rCBF predicts high grade
astrocytoma with sensitivity of 93,33%, specificity of 100%, PPV of 100%, NPV of 100%, accuracy of 94,74%. rCBF correlated positively with the grade of astrocytoma (r = 0,613, p < 0,01).
Conclusion: The rCBF plays an important role in predicting low and high grade astrocytoma. rCBF correlated positively with grade astrocytoma.
Article Details
Keywords
Astrocytoma, relative cerebral blood flow (rCBF), correlation, low and high grade of astrocytoma
References
1. Cebeci, H., et al. (2014). “Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method”. Eur J Radiol, 83(10), p. 1914-9.
2. Chawla, S., et al. (2007). “Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas”. AJNR Am J Neuroradiol, 28(9), p. 1683-9.
3. Kim, H.S. and S.Y. Kim (2007). “A prospective study on the added value of pulsed arterial spin-labeling and apparent diffusion coefficients in the grading of gliomas”. AJNR Am J Neuroradiol, 28(9), p. 1693-9.
4. Lev, M.H., et al. (2004). “Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]”. AJNR Am J Neuroradiol, 25(2), p. 214-21.
5. Louis, D.N., et al. (2007). “The 2007 WHO Classification of Tumours of the Central Nervous System”. Acta Neuropathologica, 114(2), p. 97-109.
6. Phước, L.V. (2011). “Giá trị kỹ thuật cộng hưởng từ phổ và cộng hưởng từ khuếch tán trong phân độ mô học u sao bào trước phẫu thuật”. Tạp chí y học Thành phố Hồ Chí Minh, 15(4), p. 520-526.
7. Roy, B., et al. (2013). “Comparative evaluation of 3-dimensional pseudocontinuous arterial spin labeling with
dynamic contrast-enhanced perfusion magnetic resonance imaging in grading of human glioma”. J Comput Assist Tomogr, 37(3), p. 321-6.
8. Tourdias, T., et al. (2008). “Pulsed arterial spin labeling applications in brain tumors: practical review”. J Neuroradiol, 35(2), p. 79-89.
9. Watts, J.M., C.T. Whitlow, and J.A. Maldjian (2013). “Clinical applications of arterial spin labeling”. NMR Biomed, 26(8), p. 892-900.
10. Weber, M.A., et al. (2006). “Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain
tumors”. Neurology, 66(12), p. 1899-906.
11. Wolf, R.L., et al. (2005). “Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla”. J Magn Reson Imaging, 22(4), p. 475-82.
12. Yeom, K.W., et al. (2014). “Arterial spin-labeled perfusion of pediatric brain tumors”. AJNR Am J Neuroradiol, 35(2), p. 395-401.