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Date Published: 08/07/2022
Online Published: 08/07/2022
Abstract Views: 248
Views PDF: 74
DOI: https://doi.org/10.55046/vjrnm.33.566.2019
Issue
No. 33 (2019)
Section
Scientific research
How to Cite
Tran, T. P., Nguyen, D. H., & Nguyen, D. H. (2022). Value of mr spectroscopy and perfusion in the grading of astrocytomas. Vietnamese Journal of Radiology and Nuclear Medicine, 33, 51-56. https://doi.org/10.55046/vjrnm.33.566.2019

Value of mr spectroscopy and perfusion in the grading of astrocytomas

Tran Thi Phương1, Nguyen Duy Hung1, Nguyen Duy Hue1,
1 Hanoi Medical University

Main Article Content

Abstract

SUMMARY


Objectives: The purpose of this study was to determine the value of MR spectroscopy and perfusion in the grading of astrocytomas.
Methods: A descriptive study, retrospective and prospective study, MR spectroscopy and perfusion in 27 patients with histopathological
findings of astrocytomas from 01/2016 to 07/2018 at the Viet Duc University Hospital. Evaluate the relationship between concentration of metabolics Cho, Cr, NAA, Cho/NAA, Cho/Cr, NAA/Cr; rCBV and grading of astrocytomas.
Results: The Cho/NAA and Cho/Cr ratios of the high-grade astrosytomas and low-grade astrocytomas were statistically significant (p
<0.05). The Cho/NAA ratio is useful in the diagnosis grade of astrocytomas. At the cutoff point of 2.22 for Cho/NAA ratio, MRS has sensitivity of 95%, specificity of 100%, positive predictive value of 100%, negative predictive
value of 80% for grading of astrocytomas. The rCBV index is valuable in the differential diagnosis grade of astrocytomas with the mean value of rCBV in the high-grade astrocytomas is higher than low-grade astrocytomas, there is a statistically significant difference of rCBV between the two groups. At the cutoff point of2.55 for rCBV, perfusion has sensitivity 81%, specificity
100%, positive predictive value 100%, negative predictive value 50%for grading of astrocytomas.
Conclusion: MR spectroscopy and perfusion are valuable for grading of astrocytomas.

Article Details

Keywords

MR spectroscopy, perfusion, Cho/NAA ratio, rCBV, astrocytoma, histological grade

References

TÀI LIỆU THAM KHẢO
1. Brunetti A., Alfano B., Soricelli A. et al (1996). Functional characterization of brain tumors: an overview of the potential clinical value. Nucl Med Biol, 23(6), 699-715.
2. Louis D.N., Perry A., Reifenberger G. et al (2016). The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol, 131(6), 803-20.
3. Law M., Yang S., Wang H. et al (2003). Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol, 24(10), 1989-98.
4. Lê Văn Phước, (2011). Giá trị kỹ thuật cộng hưởng từ phổ và cộng hưởng từ khuếch tán trong phân độ mô học u sao bào trước phẫu thuật Nghiên cứu y học, 15(4), 520-526.
5. Nguyễn Duy Hùng, (2017). Chẩn đoán mức độ ác tính của u thần kinh đệm trước phẫu thuật sử dụng cộng hưởng từ đa thể tích. Nghiên cứu y học, 105, 64-70.
6. Nguyễn Duy Hùng, (2016). Giá trị của cộng hưởng từ tưới máu trong chẩn đoán mức độ ác tính của u thần kinh đệm trước phẫu thuật. Nghiên cứu y học, 102, 94-100.
7. Aprile I., Torni C., Fiaschini P. et al (2012). High-Grade Cerebral Glioma Characterization: Usefulness of MR Spectroscopy and Perfusion Imaging Associated Evaluation. Neuroradiol J, 25(1), 57-66.
8. Sugahara T., Korogi Y., Kochi M. et al (2001). Perfusion-sensitive MR imaging of gliomas: comparison between
gradient-echo and spin-echo echo-planar imaging techniques. AJNR Am J Neuroradiol, 22(7), 1306-15.
9. Knopp E.A., Cha S., Johnson G. et al (1999). Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology, 211(3), 791-8.
10. Sinha S., Bastin M.E., Whittle I.R. et al (2002). Diffusion tensor MR imaging of high-grade cerebral gliomas. AJNR Am J Neuroradiol, 23(4), 520-7.