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Date Published: 08/07/2022
Online Published: 08/07/2022
Abstract Views: 112
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DOI: https://doi.org/10.55046/vjrnm.33.566.2019
Issue
No. 33 (2019)
Section
Scientific research
How to Cite
Tran, T. P., Nguyen, D. H., & Nguyen, D. H. (2022). Value of mr spectroscopy and perfusion in the grading of astrocytomas. Vietnamese Journal of Radiology and Nuclear Medicine, 33, 51-56. https://doi.org/10.55046/vjrnm.33.566.2019

Value of mr spectroscopy and perfusion in the grading of astrocytomas

Tran Thi Phương1, Nguyen Duy Hung1, Nguyen Duy Hue1,
1 Hanoi Medical University

Main Article Content

Abstract

SUMMARY


Objectives: The purpose of this study was to determine the value of MR spectroscopy and perfusion in the grading of astrocytomas.
Methods: A descriptive study, retrospective and prospective study, MR spectroscopy and perfusion in 27 patients with histopathological
findings of astrocytomas from 01/2016 to 07/2018 at the Viet Duc University Hospital. Evaluate the relationship between concentration of metabolics Cho, Cr, NAA, Cho/NAA, Cho/Cr, NAA/Cr; rCBV and grading of astrocytomas.
Results: The Cho/NAA and Cho/Cr ratios of the high-grade astrosytomas and low-grade astrocytomas were statistically significant (p
<0.05). The Cho/NAA ratio is useful in the diagnosis grade of astrocytomas. At the cutoff point of 2.22 for Cho/NAA ratio, MRS has sensitivity of 95%, specificity of 100%, positive predictive value of 100%, negative predictive
value of 80% for grading of astrocytomas. The rCBV index is valuable in the differential diagnosis grade of astrocytomas with the mean value of rCBV in the high-grade astrocytomas is higher than low-grade astrocytomas, there is a statistically significant difference of rCBV between the two groups. At the cutoff point of2.55 for rCBV, perfusion has sensitivity 81%, specificity
100%, positive predictive value 100%, negative predictive value 50%for grading of astrocytomas.
Conclusion: MR spectroscopy and perfusion are valuable for grading of astrocytomas.

Article Details

Keywords

MR spectroscopy, perfusion, Cho/NAA ratio, rCBV, astrocytoma, histological grade

References

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