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Date Published: 30/09/2022
Online Published: 30/09/2022
Abstract Views: 236
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DOI: https://doi.org/10.55046/vjrnm.48.772.2022
Issue
No. 48 (2022)
Section
Scientific research
How to Cite
Nguyen, T. K. D., Nguyen, K. T., Nguyen, M. T., Pham, D. T., & Nguyen, Q. T. (2022). EVALUATION OF 18 FLUORIN-FLUOROTHYMIDINE UPTAKE IN TUMOR-BEARING MICE. Vietnamese Journal of Radiology and Nuclear Medicine, 48, 70-75. https://doi.org/10.55046/vjrnm.48.772.2022

EVALUATION OF 18 FLUORIN-FLUOROTHYMIDINE UPTAKE IN TUMOR-BEARING MICE

Nguyen Thi Kim Dung1, Nguyen Khac That1, Nguyen Minh Thu2, Pham Dang Tung3, Nguyen Quóc Thang4
1 Department of Nuclear Medicine, Military Central Hospital 108
2 Diagnostic Imaging Center, Military Central Hospital 108
3 Faculty of Pharmacy, Phenikaa University
4 Vinmec Times City International General Hospital

Main Article Content

Abstract

PET (positron emission tomography) techniques and radiopharmaceutical tracers are becoming increasingly common. Since 1991, 3’-deoxy-3’-18Fluorine-Fluorothymidine (18F-FLT) has been studied as a PET tracer for tumor proliferation assessment. The purpose of this study was to assess tracer uptake (%ID/g) in tumor-bearing mice. Materials and methods: Two cell lines (4T1 and LLC) were inoculated into BALB/c mice. The radiotracer was then injected, and tumor resection and organ samples were performed at 20, 40, 60, 90 and 120 minutes later. A gamma-ray spectrometer was used to calculate uptake values. Results: The data show that the tumor’s %ID/g were 3,68 ± 0,29 and 5,30 ± 0,44 at 60-minute post-injection for the 4T1 and LLC tumors, respectively. In other organs, the high uptake was observed in the kidneys, spleen, and bone marrow, but a low level of tracer was seen in the brain.

Article Details

Keywords

3’-deoxy-3’-18Fluorine-Fluorothymidine, positron emission tomography, tumor-bearing mice

References

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